Janczura Miroslaw, Rosa Rafal, Dropinski Jerzy, Gielicz Anna, Stanisz Andrzej, Kotula-Horowitz Katarzyna, Domagala Teresa
Faculty of Health Sciences, Jagiellonian University School of Medicine, Krakow, Poland.
Health Care Centre of the Ministry of the Interior and Administration, Department of Anesthesiology and Intensive Care, Krakow, Poland.
Diabetes Metab Syndr Obes. 2021 Apr 23;14:1783-1797. doi: 10.2147/DMSO.S298596. eCollection 2021.
Associations between perceived stress and oxidative stress marker and metabolic syndrome (MetS) components were investigated in a cohort of police officers.
Cross-sectional data from a cohort of non-diabetic subjects (n=233; 19F), median [interquartile range] age 50 [37-44] years, were analysed. MetS was construed in line with International Diabetes Federation (IDF) criteria and perceived stress with Cohen's 10-item Perceived Stress Scale. Plasma oxidative stress marker (free 8-iso-prostaglandin F; 8-iso-PGF), presence of coronary plaque, carotid artery intima-media thickness (cIMT), and physical activity level were also determined.
Obesity was established in 100 (42.92%), hypertension in 111 (47.64), whereas MetS was identified in 104 (44.63%) of the study subjects. A significant difference (p=0.003) in plasma 8-iso-PGF level, depending on the MetS components status, was noted. The associations of perceived stress with plasma 8-iso-PGF level and the select study variables were gender-specific. In multivariate analysis (adjusted for age and current smoking), positive associations of plasma 8-iso-PGF levels with PSS score (B=0.108, 95% CI [0.008, 0.209], p=0.03) and systolic blood pressure (B=0.029, 95% CI [0.003, 0.057], p=0.02) in men only were established. Both the perceived stress (OR 1.101, 95% CI [1.001-1.202], p=0.03) and plasma 8-iso-PGF levels (OR 1.223, 95% CI [1.046-1.432], p=0.01) impacted the prevalence of hypertension. Out of the MetS components, the effect of waist circumference (OR=1.138, 95% CI [1.064-1.218], p=0.0001) and glucose (B=2.696, 95% CI [1.081-6.725], p=0.03) were also encountered. No such associations were noted in women, though, neither in univariate nor in multivariate analyses. The prevalence of coronary plaque (0.001), obesity (p<0.001), hypertension (p<0.001) and median cIMT value (p=0.005), as well as leisure-time (p=0.04) and total walking physical activity (p=0.03), differed significantly between the subgroups stratified by MetS components status.
Both the perceived and oxidative stress were found instrumental in promoting hypertension in a cohort of police officers under study, whereas all study outcomes were conclusively gender-related.
在一组警察队列中研究感知压力与氧化应激标志物及代谢综合征（MetS）各组分之间的关联。
分析了一组非糖尿病受试者（n = 233；19名女性）的横断面数据，年龄中位数[四分位间距]为50[37 - 44]岁。根据国际糖尿病联盟（IDF）标准判定MetS，并使用科恩10项感知压力量表评估感知压力。还测定了血浆氧化应激标志物（游离8 - 异前列腺素F；8 - 异 - PGF）、冠状动脉斑块的存在情况、颈动脉内膜中层厚度（cIMT）以及身体活动水平。
100名（42.92%）受试者存在肥胖，111名（47.64%）患有高血压，而104名（44.63%）研究对象被诊断为MetS。根据MetS各组分状态，血浆8 - 异 - PGF水平存在显著差异（p = 0.003）。感知压力与血浆8 - 异 - PGF水平及所选研究变量之间的关联具有性别特异性。在多变量分析中（校正年龄和当前吸烟情况），仅在男性中发现血浆8 - 异 - PGF水平与感知压力量表得分（B = 0.108，95%置信区间[0.008，0.209]，p = 0.03）及收缩压（B = 0.029，95%置信区间[0.003，0.057]，p = 0.02）呈正相关。感知压力（比值比1.101，95%置信区间[1.001 - 1.202]，p = 0.03）和血浆8 - 异 - PGF水平（比值比1.223，95%置信区间[1.046 - 1.432]，p = 0.01）均影响高血压的患病率。在MetS各组分中，还发现腰围（比值比 = 1.138，95%置信区间[1.064 - 1.218]，p = 0.0001）和血糖（B = 2.696，95%置信区间[1.081 - 6.725]，p = 0.03）有影响。然而，在女性中，无论是单变量分析还是多变量分析，均未发现此类关联。根据MetS各组分状态分层的亚组之间，冠状动脉斑块患病率（0.001）、肥胖（p < 0.001）、高血压（p < 0.001）及cIMT中位数（p = 0.005），以及休闲时间身体活动（p = 0.04）和总步行身体活动（p = 0.03）存在显著差异。
在本研究的警察队列中，感知压力和氧化应激均有助于促进高血压的发生，而所有研究结果均与性别密切相关。
