Exenatide 通过抑制细胞焦亡信号通路减轻非酒精性脂肪性肝炎。
Exenatide Attenuates Non-Alcoholic Steatohepatitis by Inhibiting the Pyroptosis Signaling Pathway.
机构信息
Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Department of Endocrinology, Heilongjiang Provincial Hospital, Harbin, China.
出版信息
Front Endocrinol (Lausanne). 2021 Apr 19;12:663039. doi: 10.3389/fendo.2021.663039. eCollection 2021.
BACKGROUND/AIMS: Exenatide is a glucagon-like polypeptide-1 analog, whose main clinical use is to treat type 2 diabetes. However, the mechanism of exenatide in mitigating non-alcoholic steatohepatitis (NASH) remains unclear. This study aimed to investigate the and effect of exenatide on NASH.
METHODS
Leptin receptor-deficient C57BL/KsJ- db/db male mice were fed with methionine-choline-deficient (MCD) diet for 4 weeks to induce NASH, while oleic acid/LPS-treated HepG2 cells were used as an cell model. Exenatide (20 µg/kg/day, subcutaneous) and specific exenatide inhibitors (20 µg/kg/day, intraperitoneal) were used to determine the effects of exenatide on NASH.
RESULTS
Exenatide treatment inhibited the pyroptosis signaling pathway to attenuate NASH.
CONCLUSION
To the best of our knowledge, this report provides the first evidence showing that exenatide attenuated NASH by inhibiting the pyroptosis signaling pathway. Exenatide thus has important pathophysiological functions in NASH and may represent a useful new therapeutic target.
背景/目的：Exenatide 是一种胰高血糖素样肽-1 类似物，其主要临床用途是治疗 2 型糖尿病。然而，Exenatide 减轻非酒精性脂肪性肝炎（NASH）的机制尚不清楚。本研究旨在探讨 Exenatide 对 NASH 的 作用和 影响。
方法
用蛋氨酸-胆碱缺乏（MCD）饮食喂养瘦素受体缺陷 C57BL/KsJ- db/db 雄性小鼠 4 周，诱导 NASH，并用油酸/LPS 处理的 HepG2 细胞作为 细胞模型。使用 Exenatide（20 µg/kg/天，皮下注射）和特异性 Exenatide 抑制剂（20 µg/kg/天，腹腔注射）来确定 Exenatide 对 NASH 的 作用。
结果
Exenatide 治疗抑制了细胞焦亡信号通路，从而减轻了 NASH。
结论
据我们所知，本报告首次提供了证据表明，Exenatide 通过抑制细胞焦亡信号通路减轻了 NASH。因此，Exenatide 在 NASH 中具有重要的病理生理功能，可能代表一个有用的新治疗靶点。
Zotero 插件