Department of Galactophore Surgery, Weifang People's Hospital, Shandong 261041, China.
Weifang Medical University, Shandong 261041, China.
Comput Math Methods Med. 2021 Apr 16;2021:8072126. doi: 10.1155/2021/8072126. eCollection 2021.
Thyroid cancer is a relatively common endocrine gland malignant tumor; if improper treatment, there will be a high risk of recurrence or metastasis, and abnormal sugar chain glycoprotein (TAP) has a close relationship with the development of the disease; therefore, the purpose of this article is to discuss abnormal sugar chain glycoprotein (TAP) as thyroid cancer curative effect evaluation and radiation and chemotherapy after surgery clinical significance. In this paper, 95 patients with thyroid cancer diagnosed in a hospital were selected as the study objects and treated as the observation group. The clinical and follow-up data of the observation group were retrospectively analyzed. Meanwhile, 55 healthy patients were randomly selected as the control group. TAP, squamous cell carcinoma antigen (SCC) level, and carcinoembryonic antigen (CEA) level were detected in peripheral blood of 95 patients with thyroid cancer before and after treatment. The short-term efficacy was evaluated by chest CT examination, and the changes of the three markers before and after treatment and the correlation with the short-term efficacy of the patients were compared. According to the results of testing, the TAP positive expression in patients before radiotherapy can better predict the recent curative effect has certain clinical value; before radiotherapy TAP positive expression rate was significantly higher than that of healthy people, TAP positive expression quantity decreased obviously after radiation treatment, and patients with a recent radiotherapy curative effect is good or bad and negatively correlated with the degree of TAP protein positive expression; TAP high protein in patients with recent poor radiation effects, prompt the factor can be predicted in the near future curative effect of the molecular markers, and can TAP level for clinicians provide certain reference for targeted therapy.
甲状腺癌是一种较为常见的内分泌腺体恶性肿瘤；若治疗不当，存在较高的复发或转移风险，异常糖链糖蛋白（TAP）与疾病的发生发展密切相关；因此，本文旨在探讨异常糖链糖蛋白（TAP）作为甲状腺癌疗效评估及术后放化疗的临床意义。选取医院收治的甲状腺癌患者 95 例作为研究对象设为观察组，回顾性分析观察组患者的临床及随访资料，同时随机选取同期 55 例健康体检者作为对照组，检测外周血 TAP、鳞癌抗原（SCC）水平、癌胚抗原（CEA）水平，采用胸部 CT 检查评估近期疗效，比较治疗前后 3 项指标的变化及其与患者近期疗效的相关性。结果检测显示，放疗前 TAP 阳性表达者更能预测近期疗效，具有一定的临床价值；放疗前 TAP 阳性表达率明显高于健康人群，放疗后 TAP 阳性表达量明显降低，且患者近期放疗疗效的好坏与 TAP 蛋白阳性表达程度呈负相关；TAP 高表达者近期放疗效果差，提示该因素可作为预测近期疗效的分子标志物，TAP 水平可为临床医生提供一定的靶向治疗参考。
