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维生素D3与促红细胞生成素联合使用可通过抑制炎症和细胞凋亡来减轻缺血再灌注诱导的急性肾损伤。

The combination of vitamin D3 and erythropoietin alleviates acute kidney injury induced by ischemia-reperfusion via inhibiting inflammation and apoptosis.

作者信息

Qin Long-Yan, Lin Xin, Liu Juan, Dong Rong, Yuan Jing, Zha Yan

机构信息

Department of Nephrology, Guizhou Provincial People's Hospital & NHC Key Laboratory of Pulmonary Immunological Disease (Guizhou Provincial People's Hospital), Guiyang, Guizhou, 550002, P.R. China.

Department of Operating Room, The First Affiliated Hospital of Guizhou University of traditional Chinese medicine, Guiyang, Guizhou, 550001, P.R. China.

出版信息

Iran J Basic Med Sci. 2021 Feb;24(2):167-174. doi: 10.22038/IJBMS.2020.51384.11661.

DOI:10.22038/IJBMS.2020.51384.11661
PMID:33953855
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8061330/
Abstract

OBJECTIVES

Acute renal ischemia may cause acute renal dysfunction due to lack of blood supply; the manifestations are renal tubular cell apoptosis, infiltration of macrophages, and microvascular destruction. Many studies have shown that erythropoietin (EPO) and vitamin D3 (VD3) can be used to prevent or treat renal ischemia-reperfusion (I/R) injury, and VD3 may interact with EPO. In the present study, the effects of the combination of VD3 and EPO in I/R acute kidney injury were studied.

MATERIALS AND METHODS

Rats were divided into 5 groups: sham-operated (SHAM), AKI without treatment (AKI-control), AKI treatment with VD3(AKI+VD3), AKI treatment with EPO(AKI+EPO), AKI treatment with VD3 and EPO(AKI+VD3+EPO). The effects of the combination of VD3 and EPO on AKI were assessed by histologic, inflammation, and apoptosis studies.

RESULTS

The degree of damage in renal tissue was significantly reduced in VD3, EPO, and combined groups. Combination therapy with VD3 and EPO markedly improved Creatinine clearance rate (CCr). The combined treatment group showed the lowest F4/80+ and CD68+ expressions. The expression of Bcl-2 in the combined treatment group was higher than those in VD3 group and the EPO group, while Bax's expression goes in the opposite direction.

CONCLUSION

This provides further evidence that VD3 and EPO have beneficial effects in I/R injury via anti-inflammatory and anti-apoptosis pathways. The synergistic protective effect of VD3 and EPO is of profound significance in the development of new strategies for the prevention and treatment of acute kidney injury (AKI).

摘要

目的

急性肾缺血可能因血液供应不足而导致急性肾功能障碍；其表现为肾小管细胞凋亡、巨噬细胞浸润和微血管破坏。许多研究表明，促红细胞生成素（EPO）和维生素D3（VD3）可用于预防或治疗肾缺血再灌注（I/R）损伤，且VD3可能与EPO相互作用。在本研究中，研究了VD3和EPO联合应用对I/R急性肾损伤的影响。

材料与方法

将大鼠分为5组：假手术组（SHAM）、未治疗的急性肾损伤组（AKI-对照）、VD3治疗的急性肾损伤组（AKI+VD3）、EPO治疗的急性肾损伤组（AKI+EPO）、VD3和EPO联合治疗的急性肾损伤组（AKI+VD3+EPO）。通过组织学、炎症和凋亡研究评估VD3和EPO联合应用对急性肾损伤的影响。

结果

VD3组、EPO组和联合治疗组肾组织损伤程度显著降低。VD3和EPO联合治疗显著提高了肌酐清除率（CCr）。联合治疗组F4/80+和CD68+表达最低。联合治疗组Bcl-2表达高于VD3组和EPO组，而Bax表达则相反。

结论

这进一步证明VD3和EPO通过抗炎和抗凋亡途径对I/R损伤具有有益作用。VD3和EPO的协同保护作用在急性肾损伤（AKI）防治新策略的开发中具有深远意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a4a/8061330/6eb957324df7/IJBMS-24-167-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a4a/8061330/54ea6d04b010/IJBMS-24-167-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a4a/8061330/4ed41ac74559/IJBMS-24-167-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a4a/8061330/b63f742930e2/IJBMS-24-167-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a4a/8061330/7211b83bcca5/IJBMS-24-167-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a4a/8061330/a940f263b508/IJBMS-24-167-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a4a/8061330/6eb957324df7/IJBMS-24-167-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a4a/8061330/54ea6d04b010/IJBMS-24-167-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a4a/8061330/4ed41ac74559/IJBMS-24-167-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a4a/8061330/b63f742930e2/IJBMS-24-167-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a4a/8061330/7211b83bcca5/IJBMS-24-167-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a4a/8061330/a940f263b508/IJBMS-24-167-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a4a/8061330/6eb957324df7/IJBMS-24-167-g006.jpg

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本文引用的文献

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Nephrol Dial Transplant. 2020 Oct 1;35(10):1729-1738. doi: 10.1093/ndt/gfz087.
2
Vitamin D: Nutrient, Hormone, and Immunomodulator.维生素 D：营养素、激素和免疫调节剂。
Nutrients. 2018 Nov 3;10(11):1656. doi: 10.3390/nu10111656.
3
Effects of erythropoietin receptor activity on angiogenesis, tubular injury, and fibrosis in acute kidney injury: a "U-shaped" relationship.
促红细胞生成素受体活性对急性肾损伤中血管生成、肾小管损伤和纤维化的影响：一种“U 型”关系。
Am J Physiol Renal Physiol. 2018 Apr 1;314(4):F501-F516. doi: 10.1152/ajprenal.00306.2017. Epub 2017 Nov 29.
4
Renoprotective effect of erythropoietin via modulation of the STAT6/MAPK/NF-κB pathway in ischemia/reperfusion injury after renal transplantation.促红细胞生成素通过调节 STAT6/MAPK/NF-κB 通路对肾移植后缺血/再灌注损伤的肾保护作用。
Int J Mol Med. 2018 Jan;41(1):25-32. doi: 10.3892/ijmm.2017.3204. Epub 2017 Oct 20.
5
No increase in the incidence of acute kidney injury in a population-based annual temporal trends epidemiology study.在一项基于人群的年度时间趋势流行病学研究中，急性肾损伤的发病率没有增加。
Kidney Int. 2017 Sep;92(3):721-728. doi: 10.1016/j.kint.2017.03.020. Epub 2017 May 18.
6
F4/80 as a Major Macrophage Marker: The Case of the Peritoneum and Spleen.作为主要巨噬细胞标志物的F4/80：以腹膜和脾脏为例
Results Probl Cell Differ. 2017;62:161-179. doi: 10.1007/978-3-319-54090-0_7.
7
Vitamin D in Chronic Kidney Disease and Dialysis Patients.慢性肾脏病及透析患者中的维生素D
Nutrients. 2017 Mar 25;9(4):328. doi: 10.3390/nu9040328.
8
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Kidney Dis (Basel). 2016 Oct;2(3):95-102. doi: 10.1159/000441887. Epub 2016 Apr 9.
9
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Lab Invest. 2017 Jan;97(1):4-13. doi: 10.1038/labinvest.2016.116. Epub 2016 Nov 21.
10
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