Innovation and Science, Amway Corporation, Ada, MI, USA.
Nutrilite Health Institute, Innovation and Science, Amway Corporation, Buena Park, CA, USA.
Photodermatol Photoimmunol Photomed. 2021 Nov;37(6):490-504. doi: 10.1111/phpp.12690. Epub 2021 May 20.
Carotenoids, a class of phytonutrients, have been well established to boost skin's innate resistance against ultraviolet (UV) B-induced erythema (sunburn). Many of the published clinical studies thus far have focused on the measurement of erythema as the primary clinical indicator of skin protection against UVB radiation. More recent studies have shown that carotenoid supplementation provides even more skin protection than previously shown as new clinical and molecular endpoints beyond UVB-induced erythema have been reported. These recent studies have demonstrated that carotenoids also provide photoprotection against UVA-induced pigmentation and inhibit molecular markers of oxidative stress such as intercellular adhesion molecule 1, heme oxygenase-1, and matrix metalloproteinases 1 and 9. This article provides a comprehensive review of the published clinical evidence on skin benefits of carotenoids in the last five decades and indicates new perspectives on the role of ingestible carotenoids in skin protection.
类胡萝卜素是一类植物营养素，已被充分证实可增强皮肤对紫外线 B（UVB）诱导红斑（晒伤）的先天抵抗力。到目前为止，许多已发表的临床研究都集中在测量红斑作为皮肤对 UVB 辐射保护的主要临床指标上。最近的研究表明，类胡萝卜素补充剂提供的皮肤保护甚至比以前显示的还要多，因为除了 UVB 诱导的红斑之外，还报告了新的临床和分子终点。这些最近的研究表明，类胡萝卜素还可以防止 UVA 诱导的色素沉着，并抑制细胞间黏附分子 1、血红素加氧酶 1 和基质金属蛋白酶 1 和 9 等氧化应激的分子标志物。本文全面回顾了过去五十年中关于类胡萝卜素对皮肤益处的已发表临床证据，并指出了可食类胡萝卜素在皮肤保护中的作用的新观点。
