School of Medicine, The University of Notre Dame Australia, Sydney, Australia.
BioEdge Newsletter, New Media Foundation, Botany, Australia.
New Bioeth. 2021 Jun;27(2):105-126. doi: 10.1080/20502877.2021.1917228. Epub 2021 May 6.
The transhumanist project of reshaping human beings by promoting their improvement through technological innovations has a broad agenda. This study focuses on the enhancement of the human organism through genetic modification techniques. Transhumanism values and a discussion of their philosophical background provide a framework to understand its ideals. Genetics and ethics are employed to assess the claims of the transhumanist program of human enhancement. A succinct description of central concepts in genetics and an explanation of current techniques to edit the human genome serve to assess the capabilities and limitations of editing techniques. Potential benefits and liabilities of human enhancement through genome editing are discussed to appraise its feasibility. Ethical considerations of genome editing inform a reflection on the implications of introducing heritable changes in the genome of individuals. It is concluded that the transhumanist program is underpinned by a large number of hypotheses rather than by sufficient evidence.
通过推动技术创新来重塑人类的超人类主义项目有一个广泛的议程。本研究侧重于通过基因修饰技术来增强人体。超人类主义价值观及其哲学背景的讨论提供了一个理解其理想的框架。遗传学和伦理学被用来评估人类增强的超人类主义计划的主张。对遗传学中的核心概念进行简洁描述,并解释当前编辑人类基因组的技术,以评估编辑技术的能力和局限性。通过基因组编辑进行人类增强的潜在益处和风险被讨论,以评估其可行性。对基因组编辑的伦理考虑为反思在个体基因组中引入可遗传变化的影响提供了信息。结论是,超人类主义计划是建立在大量假设而非充分证据的基础上的。