Kumar Vinod
Process and Technology Development Division, Defence Research & Development Establishment, Jhansi Road, Gwalior 474002, India.
Anal Methods. 2021 May 20;13(19):2248-2255. doi: 10.1039/d1ay00449b.
In view of the strong need to strengthen the national security arising from chemical terrorism, a rapid, specific, and onsite detection of chemical warfare agents (CWAs) employing a simple and easy-to-use kit is of utmost importance. Constant and sincere efforts are being carried out by the scientific community to find reliable techniques/methods for early warning detection. Herein, we designed a prototype technique in the form of a smart and portable chemical weapon detection kit (CWDK) to facilitate rapid and onsite detection. In this portable kit, a range of unique chemical probes were condensed to achieve the specific chromogenic and fluorogenic detection and discrimination of each member of blister and nerve agents. The embodiment of three chemical probes (Fc, SQ, and LH2) was eventually employed in a compact and flexible plastic packaging for detecting the presence of CWAs with the 'naked-eye' in the areas where laboratory services do not normally exist. The CWDK contains dye/reagent vials, sampling assembly, and a UV torch. The convenience and practicality of this technique suggest a great prospect for highly specific sensing of the complete class of CWAs with fast and accurate results in real-time scenarios with a sensitivity much below their lethal dose.
鉴于化学恐怖主义对加强国家安全的强烈需求，使用简单易用的试剂盒对化学战剂（CWA）进行快速、特异性和现场检测至关重要。科学界一直在持续且诚挚地努力寻找可靠的早期预警检测技术/方法。在此，我们设计了一种智能便携式化学武器检测试剂盒（CWDK）形式的原型技术，以促进快速和现场检测。在这个便携式试剂盒中，一系列独特的化学探针被浓缩在一起，以实现对糜烂性毒剂和神经性毒剂各成员的特异性显色和荧光检测及区分。最终，三种化学探针（Fc、SQ和LH2）的实施方案被用于紧凑且灵活的塑料包装中，以便在通常没有实验室服务的地区用“肉眼”检测化学战剂的存在。该CWDK包含染料/试剂瓶、采样组件和紫外线手电筒。这项技术的便利性和实用性表明，在实时场景中以远低于致死剂量的灵敏度对完整类别的化学战剂进行高度特异性传感，并能快速准确地获得结果，具有广阔的前景。
