Albert Einstein College of Medicine, Bronx, NY, USA.
Division of Gastroenterology, Montefiore Medical Center, 111 East 210th Street, Bronx, NY, 10467, USA.
Eur J Clin Microbiol Infect Dis. 2021 Sep;40(9):1963-1974. doi: 10.1007/s10096-021-04260-z. Epub 2021 May 6.
It has been demonstrated that obesity is an independent risk factor for worse outcomes in patients with COVID-19. Our objectives were to investigate which classes of obesity are associated with higher in-hospital mortality and to assess the association between obesity and systemic inflammation. This was a retrospective study which included consecutive hospitalized patients with COVID-19 in a tertiary center. Three thousand five hundred thirty patients were included in this analysis (female sex: 1579, median age: 65 years). The median body mass index (BMI) was 28.8 kg/m. In the overall cohort, a J-shaped association between BMI and in-hospital mortality was depicted. In the subgroup of men, BMI 35-39.9 kg/m and BMI ≥40 kg/m were found to have significant association with higher in-hospital mortality, while only BMI ≥40 kg/m was found significant in the subgroup of women. No significant association between BMI and IL-6 was noted. Obesity classes II and III in men and obesity class III in women were independently associated with higher in-hospital mortality in patients with COVID-19. The male population with severe obesity was the one that mainly drove this association. No significant association between BMI and IL-6 was noted.
已经证明肥胖是 COVID-19 患者预后不良的独立危险因素。我们的目的是研究哪些类别的肥胖与更高的住院死亡率相关，并评估肥胖与全身炎症之间的关系。这是一项回顾性研究，纳入了一家三级中心连续住院的 COVID-19 患者。本分析纳入了 3530 名患者（女性：1579 名，中位年龄：65 岁）。中位体重指数（BMI）为 28.8kg/m。在整个队列中，BMI 与住院死亡率之间呈现出 J 形关联。在男性亚组中，BMI 为 35-39.9kg/m 和 BMI≥40kg/m 与更高的住院死亡率显著相关，而在女性亚组中仅 BMI≥40kg/m 与更高的住院死亡率显著相关。BMI 与 IL-6 之间无显著关联。男性的肥胖类别 II 和 III 以及女性的肥胖类别 III 与 COVID-19 患者的更高住院死亡率独立相关。肥胖程度严重的男性人群是导致这种关联的主要原因。BMI 与 IL-6 之间无显著关联。
