Mitina R L, Morozova T M, Salganik R I
Biokhimiia. 1988 Apr;53(4):573-9.
In GR mice, the induction of proliferative processes in mammary tumours with ovarian hormones (estrone and progesterone) is accompanied by the activation of phosphorylation of plasma membrane, cytosolic and nuclear proteins by endogenous protein kinases. The hormones stimulate tyrosine kinases of tumour cells whose activity is as high as 14.9-17.9% of the total phosphorylation in plasma membranes and 9.5-10.4% in cell nuclei. The ovarian hormones stimulate tyrosine kinases of tumour cells which phosphorylate proteins with Mr of 110-230 and 15 kD (plasma membranes), 170, 52 and 13 kD (cytosol) and 32 kD (nuclei) which are resistant to alkaline hydrolysis. Apart from tyrosine kinases, the ovarian hormones also stimulate serine and threonine protein kinases which seems to be due to the activation of protein kinase C and other protein kinases.
在GR小鼠中，卵巢激素（雌酮和孕酮）诱导乳腺肿瘤中的增殖过程，同时内源性蛋白激酶会激活质膜、胞质和核蛋白的磷酸化。这些激素刺激肿瘤细胞的酪氨酸激酶，其活性在质膜总磷酸化中高达14.9 - 17.9%，在细胞核中为9.5 - 10.4%。卵巢激素刺激肿瘤细胞的酪氨酸激酶，这些激酶使分子量为110 - 230和15 kD（质膜）、170、52和13 kD（胞质）以及32 kD（细胞核）的蛋白质磷酸化，这些蛋白质对碱水解具有抗性。除了酪氨酸激酶外，卵巢激素还刺激丝氨酸和苏氨酸蛋白激酶，这似乎是由于蛋白激酶C和其他蛋白激酶的激活所致。
