Euromov, University of Montpellier.
Department of Behavioral Sciences and Social Medicine, College of Medicine, Florida State University.
Psychol Aging. 2021 Sep;36(6):767-772. doi: 10.1037/pag0000607. Epub 2021 May 6.
The present study examined the prospective association between subjective age and epigenetic clock in 2,253 adults (Mean age = 67.40, SD = 8.17) from the Health and Retirement Study. Subjective age and demographic factors were assessed in 2008/2010 and epigenetic clock was assessed in 2016 using the DNA methylation (DNAm) PhenoAge. Regression analysis revealed that an older subjective age was associated with accelerated epigenetic aging; mediation analysis revealed that self-rated health and CRP accounted for this association. The findings indicate that individuals who feel older than their chronological age are biologically older, in part because of their perceived health and inflammatory profiles. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
本研究在健康与退休研究（Health and Retirement Study）中，调查了 2253 名成年人（平均年龄=67.40，标准差=8.17）的主观年龄与表观遗传钟之间的前瞻性关联。2008/2010 年评估了主观年龄和人口统计学因素，2016 年使用 DNA 甲基化（DNAm）PhenoAge 评估了表观遗传钟。回归分析表明，较老的主观年龄与表观遗传衰老加速有关；中介分析表明，自我评估的健康状况和 CRP 解释了这种关联。研究结果表明，感觉自己年龄比实际年龄大的人在生理上更老，部分原因是他们的感知健康和炎症状况。（PsycInfo 数据库记录（c）2021 APA，保留所有权利）。
