Matkhanov E I, Lonshakova K S, Ubasheev I O, Azhunova T A, Mokhosoeva V K
Nauchnye Doki Vyss Shkoly Biol Nauki. 1988(4):20-4.
The morphological state of the internal organs as well the changes of microsomal oxidation in liver of white rats exposed to the action of sodium sulfate in doses 200 and 600 mg per 100 g of body weight have been studied. The sodium sulfate in dose 600 mg per 100 g of body weight has been found to decrease the cytochrome P450 content, increase its inactivation rate and have an injurious effect on the membranes of hepatocytes. Sodium sulfate administration through the gastroenteric tract causes the destructive and pathological histochemical changes in liver, stomach, duodenum and small intestine. The alternative changes are expressed most of all in duodenum and small intestine.
研究了体重每100克暴露于200毫克和600毫克硫酸钠作用下的白鼠的内脏形态状态以及肝脏微粒体氧化的变化。已发现体重每100克给予600毫克硫酸钠会降低细胞色素P450含量，提高其失活率，并对肝细胞的膜产生损伤作用。通过胃肠道给予硫酸钠会导致肝脏、胃、十二指肠和小肠出现破坏性和病理性组织化学变化。交替变化在十二指肠和小肠中表现最为明显。
