Department of Medical Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran.
Microb Drug Resist. 2021 Oct;27(10):1371-1388. doi: 10.1089/mdr.2020.0235. Epub 2021 May 5.
is the second frequent etiologic agent of mucosal and invasive candidiasis. Based on the recent developments in molecular methods, has been introduced as a complex composed of , , and . The four main classes of antifungal drugs effective against are pyrimidine analogs (flucytosine), azoles, echinocandins, and polyenes. Although the use of antifungal drugs is related to the predictable development of drug resistance, it is not clear why is able to rapidly resist against multiple antifungals in clinics. The enhanced incidence and antifungal resistance of and the high mortality and morbidity need more investigation regarding the resistance mechanisms and virulence associated with ; additional progress concerning the drug resistance of has to be further prevented. The present review highlights the mechanism of resistance to antifungal drugs in .
是黏膜和侵袭性念珠菌病的第二大常见病因。基于分子方法的最新进展，已被介绍为一种由、、和组成的复合体。有 4 类主要的抗真菌药物对有效，即嘧啶类似物（氟胞嘧啶）、唑类、棘白菌素类和多烯类。尽管抗真菌药物的使用与可预测的耐药性发展有关，但尚不清楚为什么在临床上能够迅速对多种抗真菌药物产生耐药性。和的发生率增加和抗真菌药物耐药性以及高死亡率和发病率需要更多地研究与耐药性相关的机制和与毒力相关的因素；需要进一步防止进一步的耐药性进展。本综述强调了抗真菌药物耐药性的机制。
