Significance of Mutation in Cellular Process and Disease Progression in Lung Adenocarcinoma.

(tumor protein p53) is one of the most commonly mutanted genes in lung adenocarcinoma (LUAD). In this study, we used data from The Cancer Genome Atlas (TCGA) to evaluate the importance of mutations in cellular processes, disease progression, the prognosis in LUAD, and to identify critical hub genes and pathways associated with oncogenesis. Analysis of the TCGA data showed mutations in 22% of LUAD patients. Clinicopathological analyses demonstrated that mutation was correlated with the disease progression but not prognosis. We identified 1935 differentially expressed genes (DEGs). Functional enrichment analysis showed that the DEGs were mainly concentrated in metabolism, cell differentiation, and cancer-related pathways. The top hub genes were identified and disease analysis revealed the most critical genes related to disease progression and prognosis. The expression levels of several of these genes were then tested in tumor tissues. Our results showed that mutation plays a critical role in cellular process and the clinicopathological findings in LUAD. We also identified potential key genes, which could provide novel evidence for individualized treatment.