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在退伍军人医疗中心对阿片类药物减量后的患者进行特征描述。

Characterizing Patients after Opioid Taper in a VA Medical Center.

机构信息

Kathryn Muzzio, PharmD, BCPS, Michael Chandler, PharmD, BCGP, and Lisa Dragic, PharmD, BCPS, are with the Pharmacy, Central Arkansas Veterans Healthcare System, John L. McClellan Memorial Veterans Hospital, Little Rock, Arkansas, USA; Jacob T. Painter, PharmD, MBA, PhD, is with the Core Investigator, Center for Mental Healthcare & Outcomes Research, Central Arkansas Veterans Healthcare System, Little Rock, AR Director and Associate Professor, Division of Pharmaceutical Evaluation & Policy, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

出版信息

J Pain Palliat Care Pharmacother. 2021 Jun;35(2):84-90. doi: 10.1080/15360288.2021.1900492. Epub 2021 May 6.

Abstract

To identify potential areas for intervention and gain insight on current practice in patients who are tapered to zero morphine equivalent daily doses (MEDD) through the Pharmacy Pain E-Consult at a Veterans Healthcare System. This was done by describing the types of follow-up care and resources utilized by patients. This project is a retrospective chart review of Veterans with non-cancer pain on chronic-opioid therapy consulted to the pharmacy e-consult service and tapered to 0 MEDD. Descriptive statistics are collected one year pre-taper and one year post-taper. One year post-taper, approximately one-third of the patients were re-started on opioid therapy. However, average MEDD overall was significantly decreased one year post-taper compared to pre-taper. Average pain scores were not significantly different pre-taper compared to post-taper. Non-opioid medications generally increased post-taper. Follow-up with mental health and pain management clinical pharmacy specialists decreased post-taper. Tapering to zero MEDD did not lead to a significant increase in pain one-year post-taper; however, approximately 33% of patients were re-started on opioids within one year post-taper. Average MEDD scores decreased post-taper as expected but with effects on mental health being largely unknown, we believe that further study in this area will help us better support patients.

摘要

为了确定潜在的干预领域,并深入了解通过退伍军人医疗保健系统的药房疼痛电子咨询,逐渐减少至每日吗啡当量零剂量(MEDD)的患者目前的治疗实践情况。这是通过描述患者随访护理的类型和使用的资源来实现的。该项目是对接受药房电子咨询服务并逐渐减少至每日吗啡当量零剂量(MEDD)的慢性阿片类药物治疗的非癌症疼痛退伍军人进行的回顾性图表审查。在逐渐减少 MEDD 之前一年和之后一年收集描述性统计数据。在逐渐减少 MEDD 之后一年,大约三分之一的患者重新开始使用阿片类药物治疗。然而,与逐渐减少 MEDD 之前相比,逐渐减少 MEDD 之后一年的平均 MEDD 显著降低。逐渐减少 MEDD 前后的平均疼痛评分无显著差异。逐渐减少 MEDD 后,非阿片类药物通常会增加。逐渐减少 MEDD 后,与心理健康和疼痛管理临床药剂师的随访减少。逐渐减少 MEDD 至零剂量并未导致逐渐减少 MEDD 后一年疼痛显著增加;然而,大约 33%的患者在逐渐减少 MEDD 后一年内重新开始使用阿片类药物。逐渐减少 MEDD 后,平均 MEDD 评分如预期般降低,但心理健康的影响尚不清楚,我们相信,在这一领域进一步研究将帮助我们更好地为患者提供支持。

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