Epand R M, Stafford A R, Cheetham J J, Bottega R, Ball E H
Department of Biochemistry, McMaster University Health Sciences Centre, Hamilton, Ontario.
Biosci Rep. 1988 Feb;8(1):49-54. doi: 10.1007/BF01128971.
A number of substances affect the activity of protein kinase C. Among uncharged and zwitterionic compounds, those which activate protein kinase C also lower the bilayer to hexagonal phase transition temperature of dielaidoylphosphatidylethanolamine while substances which inhibit protein kinase C raise this transition temperature. Using this criteria, we have identified 3 beta-chloro-5-cholestene, 5 beta-cholan-24-ol and eicosane as new protein kinase C activators and have shown that Z-Ser-Leu-NH2, Z-Gly-Leu-NH2, Z-Tyr-Leu-NH2, cyclosporin A and cholestan-3 beta, 5 alpha, 6 beta-triol are protein kinase C inhibitors.
