Epand R M
Biosci Rep. 1986 Jul;6(7):647-53. doi: 10.1007/BF01114759.
Virus replication inhibitory peptide (carbobenzoxy-D-Phe-L-PheGly) was shown to be a potent specific inhibitor of the replication of paramyxovirus and myxovirus (Richardson, Scheid and Choppin (1980), Virology 105, 205-222). This peptide inhibits the membrane fusing activity of a viral glycoprotein. Many agents which promote the formation of the hexagonal phase in membranes also accelerate membrane fusion. At a mole fraction of 0.1, viral replication inhibitory peptide can raise the bilayer to hexagonal phase transition temperature of dielaidoylphosphatidylethanolamine by almost 10 degrees. Two related peptides, carbobenzoxy-L-PheGly and carbobenzoxy-L-GlyPhe, are less potent in raising the bilayer to hexagonal phase transition temperature, with the latter peptide being the least effective of the three. This order of potency is the same as the order of potency in inhibiting viral replication. Substances which inhibit hexagonal phase formation of pure lipids may also inhibit membrane fusion.
病毒复制抑制肽（苄氧羰基-D-苯丙氨酸-L-苯丙氨酸甘氨酸）被证明是副粘病毒和粘液病毒复制的一种强效特异性抑制剂（理查森、谢德和乔平（1980年），《病毒学》105卷，205 - 222页）。该肽抑制病毒糖蛋白的膜融合活性。许多促进膜中六方相形成的试剂也会加速膜融合。在摩尔分数为0.1时，病毒复制抑制肽可使二月桂酰磷脂酰乙醇胺的双层到六方相转变温度提高近10度。两种相关肽，苄氧羰基-L-苯丙氨酸甘氨酸和苄氧羰基-L-甘氨酸苯丙氨酸，在提高双层到六方相转变温度方面效力较低，后一种肽在三者中效果最差。这种效力顺序与抑制病毒复制的效力顺序相同。抑制纯脂质六方相形成的物质也可能抑制膜融合。
