Department of Neurosurgery, Tosei General Hospital, Aichi, Japan.
PLoS One. 2021 May 6;16(5):e0251253. doi: 10.1371/journal.pone.0251253. eCollection 2021.
A percutaneous coronary intervention (PCI) is widely performed for acute coronary syndromes or chronic coronary syndromes. Periprocedural stroke is a clinically significant complication during PCI. The incidence of cerebrovascular events (CVEs) after PCI in the chronic phase is obscure. This study aimed to investigate the prevalence of CVEs after PCI in the chronic phase and evaluate the usefulness of a simple coronary artery calcification (CAC) evaluation method. This prospective observational study included 179 patients who underwent PCI between January 2016 and December 2018. The incidence of cerebral infarction was examined from one month after PCI to December 2019. In total, 171 individuals (134 men; mean age, 69.8 ± 9.8 years) were recruited. During a median follow-up period of 33 months, the onset of cerebral infarction was observed in 20 individuals (11.7%). More CAC sites (p = 0.009) and post-PCI for the chronic coronary syndrome (p = 0.049) showed a significant association with future CVEs. There was no significant cervical internal carotid artery stenosis for patients who occurred CVEs. The cutoff value for the number of CAC sites for predicting future CVEs was 4.5. The new and easy method accurately reflected future CVEs risk and may be clinically applicable.
经皮冠状动脉介入治疗（PCI）广泛应用于急性冠状动脉综合征或慢性冠状动脉综合征。经皮冠状动脉介入治疗过程中的卒中是一种临床意义重大的并发症。在慢性期经皮冠状动脉介入治疗后脑血管事件（CVE）的发生率尚不清楚。本研究旨在探讨慢性期经皮冠状动脉介入治疗后 CVE 的发生率，并评估一种简单的冠状动脉钙化（CAC）评估方法的实用性。这项前瞻性观察研究纳入了 179 名于 2016 年 1 月至 2018 年 12 月期间接受 PCI 的患者。从 PCI 后一个月到 2019 年 12 月，检查脑梗死的发生率。共纳入 171 名患者（男性 134 名，平均年龄 69.8 ± 9.8 岁）。在中位随访 33 个月期间，20 名患者（11.7%）出现脑梗死。更多的 CAC 部位（p = 0.009）和慢性冠状动脉综合征后的 PCI（p = 0.049）与未来 CVE 的发生有显著相关性。发生 CVE 的患者颈内动脉狭窄无明显狭窄。预测未来 CVE 的 CAC 部位数量的截断值为 4.5。新的简单方法准确反映了未来 CVE 的风险，可能具有临床应用价值。
