Department of Pharmacology, University of Maryland School of Medicine, 670 W. Baltimore St. HSF III 9179, Baltimore, MD 21201, USA.
Department of Pharmacology, University of Maryland School of Medicine, 670 W. Baltimore St. HSF III 9179, Baltimore, MD 21201, USA.
Neuron. 2021 May 5;109(9):1416-1418. doi: 10.1016/j.neuron.2021.04.013.
In this issue of Neuron, Soria-Gomez et al. (2021) investigate whether activation of the type 1 cannabinoid receptor at specific subcellular locations within a single neural circuit produces multimodal behavior. Their results demonstrate that location matters: striatonigral mitochondrial CB1 drives catalepsy while striatonigral plasma membrane CB1 receptors enable antinociception.
在本期《神经元》杂志中，Soria-Gomez 等人（2021 年）研究了在单个神经回路的特定亚细胞位置激活 1 型大麻素受体是否会产生多模态行为。他们的研究结果表明，位置很重要：纹状体苍白球线粒体 CB1 驱动僵住，而纹状体苍白球质膜 CB1 受体则可产生抗伤害作用。
