Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil.
Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil; Department of Physics, Regional University of Cariri, Juazeiro do Norte, CE, Brazil.
Microb Pathog. 2021 Jul;156:104928. doi: 10.1016/j.micpath.2021.104928. Epub 2021 May 3.
The present study aimed to investigate the antibacterial and modulatory activities of (+)-β-citronellol (βCT), β-cyclodextrin (β-CD), and their complex βCT/β-CD and characterize them using infrared spectroscopy. Infrared spectra were recorded in the 750-4000 cm region. The antibacterial effects of these compounds and their modulatory-antibiotic activities were determined using the minimum inhibitory concentration (MIC) test. Signatures of these pure compounds were detected in the infrared spectrum of the βCT/β-CD complex. The MIC of the βCT/β-CD complex against the tested strains was found to be 1024 μg/mL. The antagonistic and synergistic effects of these compounds were also observed using the modulation tests. βCT or β-CD alone did not exhibit any direct antibacterial activity. However, the βCT/β-CD complex in combination with gentamicin showed a synergistic effect against E. coli.
本研究旨在探讨（+）-β-香茅醇（βCT）、β-环糊精（β-CD）及其复合物βCT/β-CD 的抗菌和调节活性，并利用红外光谱对其进行表征。在 750-4000 cm 区域记录了红外光谱。采用最低抑菌浓度（MIC）试验测定了这些化合物的抗菌作用及其调节抗生素活性。在βCT/β-CD 复合物的红外光谱中检测到了这些纯化合物的特征。βCT/β-CD 复合物对测试菌株的 MIC 为 1024 μg/mL。通过调制试验还观察到了这些化合物的拮抗和协同作用。βCT 或 β-CD 单独使用时均没有直接的抗菌活性。然而，βCT/β-CD 复合物与庆大霉素联合使用对大肠杆菌表现出协同作用。
