Centro de Investigación Científica de Yucatán, A.C., Unidad de Materiales, Calle 43 No. 130 X 32 y 34, Chuburná de Hidalgo, CP 97205, Merida, Yucatán, Mexico.
Unidad de Energía Renovable, Carretera Sierra Papacal- Chuburna Puerto, Km. 5, C.P. 97302, Sierra Papacal, Yucatan, Mexico.
Carbohydr Res. 2021 Jun;504:108334. doi: 10.1016/j.carres.2021.108334. Epub 2021 Apr 28.
An alternative for the production of drug delivery system is proposed based on the Ceiba pentandra milkweed. The kapok cellulose was chemically crosslinked with citric acid (CA) at different CA proportions, and loaded with chlorhexidine diacetate (CHX) at different concentrations. Cellulose crosslinking was followed with FTIR and XPS analysis, and the CHX loading was determined using elemental analysis. In vitro studies showed a burst release within the first 2-3 h and the drug release kinetics was described with several models. In addition, the crosslinked Ceiba pentandra fibers did not exhibit a cytotoxic effect on human dermic fibroblasts. Results indicate that the crosslinked Ceiba pentandra fibers are a feasible material for the production of systems for drug release applications.
提出了一种基于吉贝牛奶树的药物传递系统生产的替代方法。木棉纤维素分别用不同比例的柠檬酸（CA）进行化学交联，并在不同浓度下负载洗必泰二乙酸盐（CHX）。用 FTIR 和 XPS 分析对纤维素交联进行了跟踪，用元素分析测定了 CHX 的负载量。体外研究表明，在最初的 2-3 小时内有一个爆发释放，药物释放动力学可以用几种模型来描述。此外，交联的吉贝牛奶树纤维对人体真皮成纤维细胞没有细胞毒性作用。结果表明，交联的吉贝牛奶树纤维是生产药物释放系统的一种可行材料。
