Department of Pharmaceutics, YSPM's Yashoda Technical Campus, Faculty of Pharmacy, NH4, Wadhephata, Satara 415011, Maharashtra, India.
Department of Pharmaceutics, Gourishankar Institute of Pharmaceutical Education and Research, Limb, Satara, Maharashtra, India.
Int J Biol Macromol. 2018 Oct 15;118(Pt A):783-791. doi: 10.1016/j.ijbiomac.2018.06.142. Epub 2018 Jun 28.
In present work, carboxymethylcellulose (CMC) - polyethylene glycol (PEG) hydrogel films were prepared using citric acid as a non-toxic crosslinking agent, for the controlled delivery of model hydrophobic drug (ketoconazole). The carboxyl content of the hydrogel films were determined by acid-base titration. The films were characterized by solid state C NMR, ATR-FTIR, TGA and DSC, and evaluated for swelling behavior, drug loading, drug release, hemocompatibility, in vitro cytotoxicity and implantation test. An increase in the amount of PEG caused increase in the carboxyl content and swellability of the hydrogel films. The solid state C NMR, ATR-FTIR and thermal analysis confirmed the formation of ester crosslinks in between CMC and PEG in the hydrogel films. The release of KTZ was found to be retarded due to presence of grafted PEG in the hydrogel films. The hydrogel films exhibited excellent hemocompatibility and cytocompatibility. Implantation test revealed that the hydrogel films caused minimum inflammation. From the overall results, citric acid crosslinked CMC-PEG hydrogel films were found to be suitable for enhanced loading and controlled release of the poorly soluble drugs.
在目前的工作中，使用柠檬酸作为无毒交联剂制备了羧甲基纤维素（CMC）-聚乙二醇（PEG）水凝胶薄膜，用于控制模型疏水性药物（酮康唑）的递送。通过酸碱滴定法测定水凝胶薄膜的羧基含量。通过固态 C NMR、ATR-FTIR、TGA 和 DSC 对薄膜进行了表征，并对溶胀行为、载药量、药物释放、血液相容性、体外细胞毒性和植入试验进行了评价。PEG 用量的增加导致水凝胶薄膜的羧基含量和溶胀性增加。固态 C NMR、ATR-FTIR 和热分析证实了水凝胶薄膜中 CMC 和 PEG 之间形成了酯交联。由于水凝胶薄膜中接枝了 PEG，KTZ 的释放被延迟。水凝胶薄膜表现出良好的血液相容性和细胞相容性。植入试验表明，水凝胶薄膜引起的炎症最小。从整体结果来看，柠檬酸交联的 CMC-PEG 水凝胶薄膜适合于增强负载和控制释放难溶性药物。
