Department of Hematology and Bone Marrow Transplantation Center, Ankara Oncology Training and Research Hospital, Ankara, Turkey
Department of Strategy Development, Republic of Turkey, Ministry of Health, Ankara, Turkey
Turk J Med Sci. 2021 Aug 30;51(4):1659-1664. doi: 10.3906/sag-2101-321.
BACKGROUND/AIM: SARS-CoV-2 enters the cell through the binding of the S glycoprotein on the surface of the virus to the angiotensin- converting enzyme 2 (ACE-2) in the host cells and also SARS-CoV S protein binding to ACE-2 was inhibited by anti-A antibodies. The aim of the study was to investigate the relationship between blood groups and the course of COVID-19 in Turkey.
Laboratory confirmed COVID-19 patients aged 18 and over (n = 39.850) were randomized in age and sex- matched groups according to blood groups.
Advanced age, male sex and blood group A were found to be related with increased rate of intensive care unit (ICU) admission (OR = 1.089, 95% CI: 1.085–1.093 for age; OR = 1.963, 95% CI: 1.737–2.218 for male sex; OR = 1.216, 95% CI: 1.023–1.446 for blood group A). When blood group O individuals were compared to non-O individuals, no significant difference was observed regarding the rate of hospital and ICU admission, mechanical ventilation (MV) support, length of hospital and ICU stay, and case fatality rate (CFR). The CFR in patients with blood group A, B, O, and AB were 2.6%, 2.2%, 3.1%, and 2.3%, respectively. There were no significant differences between Rh-negative and positive patients regarding the rate of hospital and ICU admission (p = 0.280 and p = 0.741, respectively), also the rate of MV support and CFR was similar (p = 0.933 and p = 0.417).
Our study revealed that ABO and Rh blood groups do not have any impact on the rate of hospital admission, hospital and ICU stay, MV support, and CFR.
背景/目的：SARS-CoV-2 通过病毒表面的 S 糖蛋白与宿主细胞中的血管紧张素转换酶 2（ACE-2）结合进入细胞，SARS-CoV 的 S 蛋白与 ACE-2 的结合也被抗-A 抗体所抑制。本研究旨在探讨土耳其人群中血型与 COVID-19 病程之间的关系。
根据血型将年龄和性别匹配的实验室确诊 COVID-19 患者（n = 39.850）随机分为年龄和性别匹配的组。
研究发现，高龄、男性和血型 A 与 ICU 入住率升高相关（OR = 1.089，95%CI：1.085-1.093 年龄；OR = 1.963，95%CI：1.737-2.218 男性；OR = 1.216，95%CI：1.023-1.446 血型 A）。与非 O 血型个体相比，O 血型个体的住院和 ICU 入住率、机械通气（MV）支持、住院和 ICU 停留时间以及病死率（CFR）无显著差异。A、B、O 和 AB 血型患者的 CFR 分别为 2.6%、2.2%、3.1%和 2.3%。Rh 阴性和阳性患者的住院和 ICU 入住率无显著差异（p = 0.280 和 p = 0.741），MV 支持率和 CFR 也相似（p = 0.933 和 p = 0.417）。
本研究表明，ABO 和 Rh 血型对住院率、住院和 ICU 停留时间、MV 支持率和 CFR 无影响。
