Ergoren Mahmut Cerkez, Akan Gokce, Guler Emrah, Tuncel Gulten, Akovalı Damla, Evren Emine Unal, Evren Hakan, Suer Huseyin Kaya, Sanlidag Tamer
Department of Medical Genetics, Faculty of Medicine, Near East University, Nicosia, Cyprus.
DESAM Research Institute, Near East University, Nicosia, Cyprus.
Glob Med Genet. 2023 Jan 30;10(1):22-26. doi: 10.1055/s-0043-1761202. eCollection 2023 Jan.
Data consisting of millions of cases cannot still explain the immunopathogenesis mechanism between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and host cell for ongoing coronavirus disease 2019 (COVID-19) pandemics. Epidemiological studies among different populations suggested different impacts of ABO and Rh antibodies on the COVID-19 susceptibility. Thus, the ABO blood group and the SARS-CoV-2 infection paradox remain unclear. Therefore, the present retrospective case-control study aimed to investigate the possible association between ABO blood groups and Rh blood types on SARS-CoV-2 infection in the Turkish Cypriot population. A total of 18,639 Turkish Cypriot subjects (297 SARS-CoV-2 COVID-19 patients and 18,342 healthy) were included in this study. Personal and clinical characteristics including age, gender, SARS-CoV-2 infection status, the ABO blood group and Rh blood types were evaluated and compared between two groups. As a result, ABO blood group was shown to be associated with a higher risk of SARS-CoV-2 infection as well as with male sex ( = 0.018). There was no association between Rh blood type and COVID-19. Overall, this study is the first largest sample group study to show the distribution of ABO blood group and Rh blood types in the healthy Turkish Cypriot population. Based on the current evidence, there are insufficient data to guide public health policies regarding COVID-19 pathogenesis.
由数百万病例组成的数据仍无法解释严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染与宿主细胞之间的免疫发病机制，而这正是当前2019冠状病毒病（COVID-19）大流行的情况。不同人群的流行病学研究表明，ABO和Rh抗体对COVID-19易感性有不同影响。因此，ABO血型与SARS-CoV-2感染之间的矛盾仍不明确。因此，本回顾性病例对照研究旨在调查土族塞人人群中ABO血型和Rh血型与SARS-CoV-2感染之间可能存在的关联。本研究共纳入18639名土族塞人受试者（297名SARS-CoV-2 COVID-19患者和18342名健康人）。对两组的个人和临床特征，包括年龄、性别、SARS-CoV-2感染状况、ABO血型和Rh血型进行了评估和比较。结果显示，ABO血型与SARS-CoV-2感染风险较高以及男性性别有关（P = 0.018）。Rh血型与COVID-19之间没有关联。总体而言，本研究是第一项最大样本量的研究，展示了健康土族塞人人群中ABO血型和Rh血型的分布情况。基于目前的证据，尚无足够数据来指导有关COVID-19发病机制的公共卫生政策。
