Beijing Key Laboratory of Construction-Tailorable Advanced Functional Materials and Green Applications, School of Materials Science & Engineering, Institute of Engineering Medicine, Beijing Institute of Technology, Beijing 100081, China.
State Key Laboratory of Heavy Oil Processing, College of New Energy, China University of Petroleum (East China), Qingdao 266580, China.
ACS Nano. 2021 May 25;15(5):8694-8705. doi: 10.1021/acsnano.1c00772. Epub 2021 May 7.
Photodynamic therapy (PDT) has shown great potential in infection treatment. However, the shallow depth of the short wavelength light and the low reactive oxygen species (ROS) production hinder its development. A strategy that can achieve a second near-infrared (NIR-II) light that is a long wavelength induced multi-intensified antibacterial PDT is most critical. Herein, hybrid plasmonic Au/CdSeS with precise Ag doping (ACA) nanodumbbells are rationally designed for ideal NIR-II light induced antibacterial PDT. Plasmonic Au nanorods extend the photocatalytic activity of ACA to NIR-II regions, which provides a basis for NIR-II light induced PDT. More importantly, multi-intensified PDT can be realized by the following creativities: (i) elaborate design of as-synthesized nanodumbbells that allows for electron holes to be redistributed in different regions simultaneously, (ii) the efficient hot-electrons injection that benefits from the ratio tailoring of anions ratio of Se and S, and (iii) the dopant Ag level inhibiting the combination of electron holes. The nanodumbbells create effective hot-electrons injection and a separation of electron holes, which provides great convenience for the production of ROS and allows NIR-II light induced PDT for the inhibition of bacteria and biofilms. As a result, comparably, our well-defined ACA hybrid nanodumbbells can generate about 40-fold superoxide radicals (·O) and more hydroxyl radicals (·OH). Therefore, the MIC value of the as-synthesized nanodumbbells is lower than the value of 1/16 of core-shell ACA. results further demonstrate that our nanodumbbells exhibit excellent PDT efficacy.
光动力疗法（PDT）在感染治疗中显示出巨大的潜力。然而，短波长光的浅层深度和低活性氧物种（ROS）产生阻碍了其发展。一个可以实现第二个近红外（NIR-II）光的策略是至关重要的，该光具有长波长诱导的多强化抗菌 PDT。在此，具有精确 Ag 掺杂（ACA）纳米哑铃的混合等离子体 Au/CdSeS 被合理设计用于理想的 NIR-II 光诱导抗菌 PDT。等离子体 Au 纳米棒将 ACA 的光催化活性扩展到 NIR-II 区域，为 NIR-II 光诱导 PDT 提供了基础。更重要的是，通过以下创意可以实现多强化 PDT：（i）精心设计的合成纳米哑铃，允许电子空穴在不同区域同时重新分布，（ii）得益于阴离子比硒和硫的比例调整的有效热电子注入，以及（iii）掺杂 Ag 水平抑制电子空穴的复合。纳米哑铃创造了有效的热电子注入和电子空穴的分离，这为 ROS 的产生提供了极大的便利，并允许 NIR-II 光诱导 PDT 抑制细菌和生物膜。结果表明，我们定义明确的 ACA 混合纳米哑铃可以产生约 40 倍的超氧自由基（·O）和更多的羟基自由基（·OH）。因此，合成纳米哑铃的 MIC 值低于核壳 ACA 的 1/16。结果进一步证明了我们的纳米哑铃具有优异的 PDT 效果。
