Osther P J, Hansen A B, Røhl H F
Department of Urology, Odense University Hospital, Denmark.
Br J Urol. 1988 May;61(5):392-4. doi: 10.1111/j.1464-410x.1988.tb06581.x.
Thirteen patients with medullary sponge kidney underwent a short ammonium chloride loading test to investigate their renal acidification capacity. All but 1 presented with a history of recurrent renal calculi and showed bilateral widespread renal medullary calcification on X-ray examination. Nine patients had some form of renal acidification defect; 8 had the distal type of renal tubular acidosis, 2 the complete and 6 the incomplete form. One patient had proximal renal tubular acidosis. These findings, which suggest that renal acidification defects play an important role in the pathogenesis of renal calculi in medullary sponge kidney, have considerable therapeutic implications.
13例髓质海绵肾患者接受了短程氯化铵负荷试验，以研究其肾脏酸化能力。除1例患者外，其余患者均有复发性肾结石病史，X线检查显示双侧肾髓质广泛钙化。9例患者存在某种形式的肾脏酸化缺陷；8例为远端肾小管酸中毒，其中2例为完全型，6例为不完全型。1例患者为近端肾小管酸中毒。这些发现提示肾脏酸化缺陷在髓质海绵肾结石的发病机制中起重要作用，具有重要的治疗意义。
