Osther P J, Rasmussen L, Pedersen S A
Department of Surgery K, Odense University Hospital, Denmark.
Int Urol Nephrol. 1992;24(3):229-31. doi: 10.1007/BF02549529.
Urinary pH is related to urinary calculus formation as well as urinary infection. Omeprazole is an effective inhibitor of gastric acid secretion through inhibition of the parietal cell H+K+ATPase. In this study we have evaluated a possible effect of omeprazole on urine acidification. Ten healthy male subjects took placebo and omeprazole, 40 mg o.m., for 10 days in a double-blind placebo-controlled trial. Morning fasting urinary pH was measured on day 10 of each treatment course using a pH meter. No effect of omeprazole on urinary pH could be demonstrated. It is thus unlikely that it is necessary to take omeprazole treatment into consideration in stone screening. As omeprazole did not affect urinary pH, no urological side effects related to changes in urinary pH can be expected.
尿液pH值与尿路结石形成以及泌尿系统感染有关。奥美拉唑是一种通过抑制壁细胞H⁺K⁺ATP酶来有效抑制胃酸分泌的药物。在本研究中，我们评估了奥美拉唑对尿液酸化的可能影响。在一项双盲安慰剂对照试验中，10名健康男性受试者服用安慰剂和40毫克口服奥美拉唑，为期10天。在每个治疗疗程的第10天，使用pH计测量早晨空腹时的尿液pH值。未证明奥美拉唑对尿液pH值有影响。因此，在结石筛查中考虑使用奥美拉唑治疗不太可能是必要的。由于奥美拉唑不影响尿液pH值，预计不会出现与尿液pH值变化相关的泌尿系统副作用。
