Research Author, Emory University, Atlanta, Georgia.
Emory University and Children's Healthcare of Atlanta, Atlanta, Georgia.
J Am Coll Radiol. 2021 May;18(5S):S199-S211. doi: 10.1016/j.jacr.2021.02.020.
In children, seizures represent an extremely heterogeneous group of medical conditions ranging from benign cases, such as a simple febrile seizure, to life-threatening situations, such as status epilepticus. Underlying causes of seizures also represent a wide range of pathologies from idiopathic cases, usually genetic, to a variety of acute and chronic intracranial or systemic abnormalities. This document discusses appropriate utilization of neuroimaging tests in a child with seizures. The clinical scenarios in this document take into consideration different circumstances at the time of a child's presentation including the patient's age, precipitating event (if any), and clinical and electroencephalogram findings and include neonatal seizures, simple and complex febrile seizures, post-traumatic seizures, focal seizures, primary generalized seizures in a neurologically normal child, and generalized seizures in neurologically abnormal child. This practical approach aims to guide clinicians in clinical decision-making and to help identify efficient and appropriate imaging workup. The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision include an extensive analysis of current medical literature from peer reviewed journals and the application of well-established methodologies (RAND/UCLA Appropriateness Method and Grading of Recommendations Assessment, Development, and Evaluation or GRADE) to rate the appropriateness of imaging and treatment procedures for specific clinical scenarios. In those instances where evidence is lacking or equivocal, expert opinion may supplement the available evidence to recommend imaging or treatment.
在儿童中,癫痫发作是一组极其异质的医学病症,从良性病例(如单纯热性惊厥)到危及生命的情况(如癫痫持续状态)都有涉及。癫痫发作的潜在病因也涉及从特发性病例(通常是遗传的)到各种急性和慢性颅内或全身异常的广泛病理学。本文讨论了在癫痫发作儿童中适当使用神经影像学检查的问题。本文中的临床情况考虑了儿童就诊时的不同情况,包括患者的年龄、诱发事件(如有)以及临床和脑电图发现,并包括新生儿癫痫发作、单纯和复杂热性惊厥、创伤后癫痫发作、局灶性癫痫发作、神经正常儿童的原发性全身性癫痫发作以及神经异常儿童的全身性癫痫发作。这种实用方法旨在指导临床医生进行临床决策,并帮助确定有效和适当的影像学检查。美国放射学院的适宜性标准是针对特定临床情况的循证指南,每年由多学科专家小组进行审查。指南的制定和修订包括对同行评议期刊上的现有医学文献进行广泛分析,并应用成熟的方法(RAND/UCLA 适宜性方法和推荐评估、制定和评估分级或 GRADE)来评估特定临床情况下影像学和治疗程序的适宜性。在缺乏证据或证据不确定的情况下,专家意见可以补充现有证据,以推荐进行影像学检查或治疗。