Johns Hopkins Greenberg Bladder Cancer Institute, 600 North Wolfe Street, Park 219, Baltimore, MD 21287, USA.
Hematol Oncol Clin North Am. 2021 Jun;35(3):457-468. doi: 10.1016/j.hoc.2021.02.009. Epub 2021 Apr 18.
Recently completed studies provided high-resolution descriptions of the molecular biological characteristics of urothelial bladder cancers. Whole transcriptome messenger RNA expression profiling revealed that they can be grouped into basal and luminal molecular subtypes resembling the ones described in breast cancers. Retrospective DNA sequencing efforts revealed roles for disruption of DNA damage response pathways in response to conventional chemotherapy and immune checkpoint blockade, and completed and ongoing studies indicate that the molecular biological properties of infiltrating host cells dictate also influence therapeutic outcomes. This article reviews these findings and identify gaps in knowledge that represent opportunities for future research.
最近完成的研究提供了关于尿路上皮膀胱癌分子生物学特征的高分辨率描述。全转录信使 RNA 表达谱分析显示，它们可以分为基底和腔型分子亚型，类似于乳腺癌中描述的亚型。回顾性 DNA 测序研究揭示了 DNA 损伤反应通路的破坏在常规化疗和免疫检查点阻断中的作用，已完成和正在进行的研究表明，浸润宿主细胞的分子生物学特性也会影响治疗效果。本文综述了这些发现，并确定了知识空白，这些空白为未来的研究提供了机会。
