Stone W S, Gold P E
Department of Psychology, University of Virginia, Charlottesville 22903-2477.
Brain Res. 1988 May 24;449(1-2):135-40. doi: 10.1016/0006-8993(88)91031-1.
Sleep disturbances accompany the development of amygdaloid-kindled seizures in cats. Some of these sleep deficits resemble those seen in aged rats; these latter changes in sleep patterns are correlated with memory impairments in the aged animals. In the present study, we examined the hypothesis that sleep deficits after kindling may be related to memory impairments. Rats were kindled for 4 weeks (2-2.5 weeks after stage 5 seizures) and were then allowed a one week recovery period. Sleep patterns were assessed through-out the kindling and recovery periods. The animals were then trained on an inhibitory avoidance apparatus and tested for retention 24 h later. Only transient sleep changes occurred during the development of kindling (to stage 5 seizures). However, continued kindling resulted in significant reductions in several sleep measures which remained depressed for at least one week after the termination of the kindling trials. As a group, kindled rats were impaired in retention of the inhibitory avoidance learned response. In kindled animals, retention performance was significantly correlated with total paradoxical sleep, the ratio of paradoxical/total sleep, and paradoxical sleep, the ratio of paradoxical/total sleep, and paradoxical sleep bout duration. These correlations are consistent with the view that deficits in paradoxical sleep may be related to deficits in some forms of memory.
睡眠障碍伴随着猫杏仁核点燃性癫痫发作的发展。其中一些睡眠缺陷类似于老年大鼠中观察到的情况；这些睡眠模式的后期变化与老年动物的记忆障碍相关。在本研究中，我们检验了点燃后睡眠缺陷可能与记忆障碍有关的假设。大鼠被点燃4周（达到5期癫痫发作后2 - 2.5周），然后给予一周的恢复期。在整个点燃期和恢复期评估睡眠模式。然后让动物在抑制性回避装置上进行训练，并在24小时后测试记忆保持情况。在点燃发展到（5期癫痫发作）期间仅出现短暂的睡眠变化。然而，持续点燃导致几种睡眠指标显著降低，在点燃试验结束后至少一周这些指标仍处于较低水平。作为一个群体，点燃的大鼠在抑制性回避学习反应的记忆保持方面受损。在点燃的动物中，记忆保持表现与总快速眼动睡眠、快速眼动睡眠/总睡眠的比率以及快速眼动睡眠发作持续时间显著相关。这些相关性与快速眼动睡眠缺陷可能与某些形式的记忆缺陷有关的观点一致。
