Lammers J H, Kruk M R, Meelis W, van der Poel A M
Department of Pharmacology, University of Leiden, The Netherlands.
Brain Res. 1988 May 24;449(1-2):294-310. doi: 10.1016/0006-8993(88)91045-1.
The hypothalamic response area for electrically induced locomotion was determined using moveable electrodes and discriminant analysis as an appropriate statistical technique. At 241 out of 641 stimulated sites locomotion was induced. The distribution of locomotion sites is relatively diffuse. Discriminant analysis of both positive and negative electrode localizations yields areas with high, intermediate or low probability of inducing the response. The response is considered to be mediated by fibres of the subpallido-pedunculopontine system, which includes the mesencephalic locomotor region. Different categories of exploratory and flight-directed locomotion were distinguished, and response areas for both categories were determined. In addition the response area for escape jumps was delimited. Exploratory locomotion is mainly induced from the lateral hypothalamus, while flight-directed locomotion and escape jumps are evoked from the medial hypothalamus. The response area for exploratory locomotion reflects the lateral hypothalamic distribution of the subpallidal projection to the mesencephalic locomotor region. A diffuse substrate for flight behavior seems to occupy almost the entire medial hypothalamus. It is concluded that a locomotor subroutine subserving different behavioural mechanisms can be activated at many hypothalamic sites.
使用可移动电极并采用判别分析作为合适的统计技术，确定了电诱导运动的下丘脑反应区域。在641个受刺激部位中，有241个部位诱导出了运动。运动部位的分布相对分散。对正电极和负电极定位进行判别分析，得出了诱导反应概率高、中或低的区域。该反应被认为是由苍白球-脚桥系统的纤维介导的，该系统包括中脑运动区。区分了不同类型的探索性运动和导向飞行运动，并确定了这两种运动的反应区域。此外，还划定了逃避跳跃的反应区域。探索性运动主要由下丘脑外侧诱导，而导向飞行运动和逃避跳跃则由下丘脑内侧诱发。探索性运动的反应区域反映了苍白球向中脑运动区投射在下丘脑外侧的分布。一种用于飞行行为的弥散性基质似乎占据了几乎整个下丘脑内侧。得出的结论是，服务于不同行为机制的运动子程序可在下丘脑的许多部位被激活。
