Perrain Rebecca, Calvet David, Guiraud Vincent, Mekaoui Lila, Mas Jean-Louis, Gorwood Philip
GHU Paris Psychiatrie et Neurosciences, CMME, Hôpital Sainte-Anne, Paris, France.
University of Paris, Paris, France.
Neuropsychiatr Dis Treat. 2021 Apr 29;17:1243-1251. doi: 10.2147/NDT.S294722. eCollection 2021.
Post-stroke depression (PSD) affects one third of stroke survivors, with multiple severe negative consequences. We aim to assess the weight of four different types of clinical risk factors for PSD.
We conducted a prospective cohort study in a stroke centre. After stroke, patients were assessed for cognitive performances, psychiatric standardized questionnaires and socio-demographic features. They were called three months after and assessed for major depressive episode using DSM criteria.
PSD was diagnosed in 8 of the 59 (13.6%) patients enrolled in the study. After multivariate analysis, only "previous history of depressive episode" remained a significant predictive factor for PSD, the model explaining 19% of the total variance (OR=18.0; p=0.002). Patients with a previous history of depression had a 10-fold increased risk for PSD.
Previous history of depression is confirmed as a strong risk factor for PDS and allow the identification of an at-risk sub-group of patients.
中风后抑郁（PSD）影响三分之一的中风幸存者，会产生多种严重的负面后果。我们旨在评估PSD四种不同类型临床风险因素的权重。
我们在一个中风中心进行了一项前瞻性队列研究。中风后，对患者进行认知能力、精神科标准化问卷和社会人口学特征评估。三个月后对他们进行回访，并使用《精神疾病诊断与统计手册》标准评估是否发生重度抑郁发作。
该研究纳入的59名患者中有8名（13.6%）被诊断为PSD。多变量分析后，只有“既往抑郁发作史”仍然是PSD的一个显著预测因素，该模型解释了总方差的19%（比值比=18.0；p=0.002）。有抑郁发作史的患者患PSD的风险增加了10倍。
抑郁发作史被确认为PDS的一个强有力的风险因素，并且有助于识别出有风险的患者亚组。
