小胶质细胞参与卒中后抑郁的免疫炎症反应：证据综述。
Microglia Involves in the Immune Inflammatory Response of Poststroke Depression: A Review of Evidence.
机构信息
Shandong Mental Health Center, Shandong University, Jinan, Shandong 250014, China.
Neck-Shoulder and Lumbocrural Pain Hospital of Shandong First Medical University, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250062, China.
出版信息
Oxid Med Cell Longev. 2022 Aug 2;2022:2049371. doi: 10.1155/2022/2049371. eCollection 2022.
Abstract
Poststroke depression (PSD) does not exist before and occurs after the stroke. PSD can appear shortly after the onset of stroke or be observed in the weeks and months after the acute or subacute phase of stroke. The pathogenesis of PSD is unclear, resulting in poor treatment effects. With research advancement, immunoactive cells in the central nervous system, particularly microglia, play a role in the occurrence and development of PSD. Microglia affects the homeostasis of the central nervous system through various factors, leading to the occurrence of depression. The research progress of microglia in PSD has been summarized to review the evidence regarding the pathogenesis and treatment target of PSD in the future.
摘要
脑卒中后抑郁（PSD）在脑卒中之前并不存在，而是在脑卒中之后出现。PSD 可以在脑卒中发作后不久出现，也可以在脑卒中的急性期或亚急性期后数周或数月观察到。PSD 的发病机制尚不清楚，导致治疗效果不佳。随着研究的进展，中枢神经系统中的免疫活性细胞，特别是小胶质细胞，在 PSD 的发生和发展中起作用。小胶质细胞通过各种因素影响中枢神经系统的内稳态，导致抑郁的发生。本文对小胶质细胞在 PSD 中的研究进展进行综述，以期为今后 PSD 的发病机制和治疗靶点的研究提供依据。
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