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局部麻醉药的眼部肌毒性作用。

Ocular myotoxic effects of local anesthetics.

作者信息

Rao V A, Kawatra V K

机构信息

Department of Ophthalmology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.

出版信息

Can J Ophthalmol. 1988 Jun;23(4):171-3.

PMID:3395920
Abstract

Of 650 patients who underwent various surgical procedures on the anterior segment in which 2% lidocaine hydrochloride plus 1:100,000 epinephrine was used as a local anesthetic, 5 experienced postoperative complications attributed to the anesthetic: ptosis (in 2 cases), horizontal rectus muscle palsy (in 2) and lagophthalmos (in 1). The cause of the complications may have been inadvertent direct infiltration of the anesthetic into the levator palpebrae superioris, the horizontal rectus muscles and the orbicularis oculi respectively. All the patients recovered spontaneously in 8 to 12 weeks. The clinical course was compatible with myotoxic effects of local anesthetics.

摘要

在650例接受前段各种外科手术的患者中,使用2%盐酸利多卡因加1:100,000肾上腺素作为局部麻醉剂,有5例出现了归因于麻醉剂的术后并发症:上睑下垂(2例)、水平直肌麻痹(2例)和兔眼症(1例)。并发症的原因可能分别是麻醉剂意外直接浸润到提上睑肌、水平直肌和眼轮匝肌中。所有患者均在8至12周内自发恢复。临床病程与局部麻醉剂的肌毒性作用相符。

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Bupivacaine crystal deposits after long-term epidural infusion.长期硬膜外输注后布比卡因晶体沉积。
Anaesthesist. 2013 Jul;62(7):543-8. doi: 10.1007/s00101-013-2179-5. Epub 2013 May 15.
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[Myotoxicity of local anaesthetics: experimental myth or clinical truth?].
[局部麻醉药的肌毒性:实验虚构还是临床事实?]
Anaesthesist. 2007 Feb;56(2):118-27. doi: 10.1007/s00101-006-1121-5.
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Complications of regional anaesthesia Incidence and prevention.区域麻醉的并发症 发生率及预防
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Adverse effects and drug interactions associated with local and regional anaesthesia.与局部和区域麻醉相关的不良反应及药物相互作用。
Drug Saf. 1998 Apr;18(4):221-50. doi: 10.2165/00002018-199818040-00001.
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Regional anaesthesia for intraocular surgery.眼科手术的区域麻醉
Can J Anaesth. 1993 Jul;40(7):635-57. doi: 10.1007/BF03009701.
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Anaesthesia for ophthalmic surgery.眼科手术麻醉
Br J Ophthalmol. 1993 Sep;77(9):542-3. doi: 10.1136/bjo.77.9.542.