Cambridge Infinitus Research Centre, Department of Chemical Engineering and Biotechnology, University of Cambridge, West Cambridge Site, Philippa Fawcett Drive, Cambridge CB3 0AS, UK.
Research Institute for Food Nutrition and Human Health, School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China.
Oxid Med Cell Longev. 2021 Apr 19;2021:8842926. doi: 10.1155/2021/8842926. eCollection 2021.
Oxidative stress results when the production of oxidants outweighs the capacity of the antioxidant defence mechanisms. This can lead to pathological conditions including cancer and neurodegeneration. Consequently, there is considerable interest in compounds with antioxidant activity, including those from natural sources. Here, we characterise the antioxidant activity of three novel peptides identified in protein hydrolysates from the sea cucumber . Under oxidative stress conditions, synthetic versions of the sea cucumber peptides significantly compensate for glutathione depletion, decrease mitochondrial superoxide levels, and alleviate mitophagy in human neuroblastoma cells. Moreover, orally supplied peptides improve survival of the after treatment with paraquat, the latter of which leads to the production of excessive oxidative stress. Thus, the sea cucumber peptides exhibit antioxidant activity at both the cellular and organism levels and might prove attractive as nutritional supplements for healthy ageing.
当氧化剂的产生超过抗氧化防御机制的能力时，就会发生氧化应激。这可能导致包括癌症和神经退行性变在内的病理状况。因此，人们对具有抗氧化活性的化合物，包括来自天然来源的化合物，产生了浓厚的兴趣。在这里，我们描述了从海参蛋白质水解物中鉴定出的三种新型肽的抗氧化活性。在氧化应激条件下，海参肽的合成版本显著补偿了谷胱甘肽的消耗，降低了线粒体超氧化物水平，并减轻了人神经母细胞瘤细胞中的自噬。此外，口服供给的肽可提高百草枯处理后的 的存活率，后者会导致过度氧化应激的产生。因此，海参肽在细胞和机体水平均表现出抗氧化活性，并且可能作为健康衰老的营养补充剂具有吸引力。
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