Orr Cody, Masur Henry, Kottilil Shyam, Meissner Eric G
Division of Infectious Diseases, Medical University of South Carolina, Charleston, South Carolina, USA.
Critical Care Medicine Department, NIH Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
Open Forum Infect Dis. 2021 Mar 13;8(4):ofab118. doi: 10.1093/ofid/ofab118. eCollection 2021 Apr.
To identify immunologic correlates of hepatitis C virus (HCV) relapse after direct-acting antiviral (DAA) therapy, we quantified select immune transcripts in whole blood from noncirrhotic HCV subjects treated with 4-6 weeks of DAAs. We identified specific markers of natural killer-cell and CD8 T-cell function (, , ) with higher expression in subjects who relapsed. These findings suggest a role for host immunity in HCV eradication with ultrashort DAA therapy. We quantified whole blood immune transcripts in noncirrhotic HCV subjects treated with shortcourse antiviral therapy. Markers of natural killer-cell and CD8+ T-cell function had higher expression in virologic relapsers, suggesting a role for host immunity in HCV eradication.
为了确定直接抗病毒药物（DAA）治疗后丙型肝炎病毒（HCV）复发的免疫相关因素，我们对接受4-6周DAA治疗的非肝硬化HCV患者全血中的特定免疫转录本进行了定量分析。我们鉴定出自然杀伤细胞和CD8 T细胞功能的特异性标志物（……），在复发患者中表达较高。这些发现表明宿主免疫在超短程DAA治疗清除HCV中发挥作用。我们对接受短疗程抗病毒治疗的非肝硬化HCV患者的全血免疫转录本进行了定量分析。自然杀伤细胞和CD8+ T细胞功能标志物在病毒学复发者中表达较高，提示宿主免疫在清除HCV中发挥作用。
