复发期急性非淋巴细胞白血病的细胞遗传学研究

Cytogenetic studies on acute nonlymphocytic leukemia in relapse.

作者信息

Berger R, Le Coniat M, Derré J, Vecchione D, Pacot A, Chen S J, Baranger L, Bernheim A

机构信息

Laboratoire d'Oncologie et d'Immunohématologie, L.O.I., LP 101 (CNRS), Hopital Saint Louis, Paris, France.

出版信息

Cancer Genet Cytogenet. 1988 Aug;34(1):11-8. doi: 10.1016/0165-4608(88)90161-6.

DOI:10.1016/0165-4608(88)90161-6

PMID:3395983

Abstract

Karyotypic abnormalities were compared in 42 acute nonlymphocytic leukemia patients at diagnosis and in relapse. Clonal changes were observed in 21 cases. The types of changes were the appearance of clonal abnormalities in relapse in four patients without clonal changes at diagnosis, the detection of new abnormalities superimposed on preexisting ones in 11 cases, and the selection of an abnormal clone in six others. Nonclonal structural abnormalities, mainly involving chromosomes 17 and 12p, were detected in relapse in 17 patients, compared to seven at diagnosis. The appearance of totally new clonal changes at relapse and the role of individual sensitivity to chemotherapy are discussed.

摘要

对42例急性非淋巴细胞白血病患者在诊断时和复发时的核型异常进行了比较。观察到21例有克隆性改变。改变类型包括：4例诊断时无克隆性改变的患者在复发时出现克隆性异常；11例检测到新的异常叠加在先前存在的异常上；另外6例选择了一个异常克隆。17例患者在复发时检测到非克隆性结构异常，主要涉及17号和12p染色体，而诊断时为7例。讨论了复发时全新克隆性改变的出现以及个体对化疗敏感性的作用。