非淋巴细胞白血病患者的细胞遗传学随访。II. 急性非淋巴细胞白血病。

Cytogenetic follow-up of patients with nonlymphocytic leukemia. II. Acute nonlymphocytic leukemia.

作者信息

Hagemeijer A, Hählen K, Abels J

出版信息

Cancer Genet Cytogenet. 1981 Mar;3(2):109-24. doi: 10.1016/0165-4608(81)90065-0.

Abstract

Bone marrow (BM) karyotypes of 86 patients with acute nonlymphocytic leukemia (ANLL) were studied at the time of diagnosis: 39 of them (45%) were normally diploid and 47 (55%) showed acquired abnormalities. The median survival was no longer in the diploid group than in the aneuploid one. Nonrandom aberrations were often found: trisomy 8 (15 times), monosomy 7 (7 times), and t(8;21) (7 times). Two patients with acute promyelocytic leukemia presented with the t(15;17) in BM cells. Serial cytogenetic studies performed in 17 cases showed that karyotypic evolution closely followed the clinical evolution. Complete remission, obtained in 10 cases, was characterized by BM metaphases with a normal karyotype. Relapse after a period of complete remission was documented four times; the BM metaphases then showed the original abnormal karyotype with additional changes that, in three cases, were limited to a new structural aberration.

摘要

对86例急性非淋巴细胞白血病（ANLL）患者诊断时的骨髓（BM）核型进行了研究：其中39例（45%）为正常二倍体，47例（55%）显示获得性异常。二倍体组的中位生存期并不比非整倍体组长。常发现非随机畸变：8号染色体三体（15次）、7号染色体单体（7次）和t(8;21)（7次）。2例急性早幼粒细胞白血病患者骨髓细胞出现t(15;17)。对17例患者进行的系列细胞遗传学研究表明，核型演变与临床演变密切相关。10例患者获得完全缓解，其特征为骨髓中期核型正常。完全缓解一段时间后记录到4次复发；此时骨髓中期显示原始异常核型并有额外变化，其中3例仅限于新的结构畸变。