低分化肉瘤中异常条带区域与c-MYC或c-MOS原癌基因的扩增无关。
Abnormally banded region in a poorly differentiated sarcoma is not correlated with amplification of c-MYC or c-MOS protooncogenes.
作者信息
Kakati S, Limon J, Dal Cin P, Pietrzak E, Kinniburgh A J, Li F P, Sandberg A A
机构信息
Roswell Park Memorial Institute, Buffalo, New York.
出版信息
Cancer Genet Cytogenet. 1988 Aug;34(1):111-5. doi: 10.1016/0165-4608(88)90175-6.
PMID:3395984
Abstract
A poorly differentiated sarcoma in a 32-year-old female revealed a large, abnormally banded region in one chromosome #8 in all metaphases. The modal karyotype was 46,XX, -8, +mar. Southern blot hybridization was performed with probes for two protooncogenes located in chromosome 8q (c-MYC and c-MOS). No amplification or rearrangement was observed to account for the cytogenetic abnormality.
摘要
一名32岁女性的低分化肉瘤在所有中期相中均显示出8号染色体上有一个大的、异常带纹区域。核型模式为46,XX, -8, +mar。用位于8q染色体上的两个原癌基因（c-MYC和c-MOS）的探针进行了Southern印迹杂交。未观察到扩增或重排来解释细胞遗传学异常。
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