在低分化人胃癌中c-myc和c-erbB-2癌基因的共扩增

Co-amplification of c-myc and c-erbB-2 oncogenes in a poorly differentiated human gastric cancer.

作者信息

Tsuchiya T, Ueyama Y, Tamaoki N, Yamaguchi S, Shibuya M

机构信息

Department of Genetics, University of Tokyo.

出版信息

Jpn J Cancer Res. 1989 Oct;80(10):920-3. doi: 10.1111/j.1349-7006.1989.tb01626.x.

DOI:10.1111/j.1349-7006.1989.tb01626.x

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5917887/

Abstract

c-erbB-2 oncogene has been reported to be frequently amplified in differentiated, tubular type of gastric cancer. Here we report a human gastric cancer which bore co-amplified c-myc and c-erbB-2 oncogenes: a portion of the amplified c-erbB-2 oncogene was found to be rearranged. Furthermore, c-myc and c-erbB-2 oncogenes were over-expressed in the tumor cells. In contrast to the previous reports, this gastric adenocarcinoma was classified as a poorly differentiated type, and was highly tumorigenic in nude mice. These results might suggest that activated c-myc and c-erbB-2 oncogenes co-operate and influence the malignant state of some gastric carcinomas.

摘要

据报道，c-erbB-2癌基因在分化型管状胃癌中经常扩增。在此，我们报告一例同时扩增c-myc和c-erbB-2癌基因的人类胃癌：发现部分扩增的c-erbB-2癌基因发生了重排。此外，c-myc和c-erbB-2癌基因在肿瘤细胞中过度表达。与之前的报道不同，该胃腺癌被归类为低分化型，并且在裸鼠中具有高度致瘤性。这些结果可能表明，激活的c-myc和c-erbB-2癌基因相互协作并影响某些胃癌的恶性状态。

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