在具有t(8;21)(q22;q22)的白血病细胞中，人c-mos基因定位于染色体8q11带。
Localization of human c-mos to chromosome band 8q11 in leukemic cells with the t(8;21) (q22;q22).
作者信息
Morris C M, Bowen J, Fitzgerald P H
机构信息
Cancer Society of New Zealand Cytogenetic and Molecular Oncology Unit, Christchurch Hospital, New Zealand.
出版信息
Hum Genet. 1989 Mar;81(4):339-42. doi: 10.1007/BF00283687.
Chromosome in situ hybridization studies locate c-mos to chromosome band 8q11 in leukemic cells carrying the t(8;21) (q22;q22). This amends the previous assignment of c-mos to chromosome band 8q22 and conforms with its recent assignment to 8q11 in normal cells and in a cell line with a structurally abnormal chromosome 8. C-mos lies proximally to, and distant from, the breakpoint at 8q22 in the t(8;21) and is unlikely to have a role in the onset of acute myeloid leukemia characterized by this translocation.
染色体原位杂交研究将c-mos定位于携带t(8;21)(q22;q22)的白血病细胞中的8q11染色体带。这修正了之前将c-mos定位于8q22染色体带的结果，并且与最近在正常细胞和具有结构异常的8号染色体的细胞系中定位于8q11的结果一致。在t(8;21)中，c-mos位于8q22的断点近端且距离较远，不太可能在由这种易位所导致的急性髓系白血病的发病过程中起作用。
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