Sancassiani Federica, Massa Elena, Pibia Carla, Perda Giulia, Boe Laura, Fantozzi Elena, Cossu Giulia, Caocci Giovanni, Mulas Olga, Morelli Emanuela, Lindert Jutta, Lai Eleonora, Nardi Antonio Egidio, Scartozzi Mario, La Nasa Giorgio, Carta Mauro Giovanni
Department of Medical Sciences and Public Health, University of Cagliari.
Department of Medical Sciences and Public Health, University of Cagliari, Italy .
J Public Health Res. 2021 May 5;10(3):2247. doi: 10.4081/jphr.2021.2247.
the aim was to verify the association between Major Depressive Disorders (MDD) and the risk of premature death in people with oncological diseases, and to collect evidence about the causality of a possible association from a longitudinal perspective.
it is a cohort study lasting 9 months, involving people with solid or hematologic cancers. The assessment was conducted by an ad hoc form to collect socio-demographic and clinical-oncological data, the PHQ-9 to screen MDD (cut-off ≥10) and the SF-12 to evaluate HRQoL. Relative Risk (RR) of early death between MDD exposed and not-exposed and Kaplan-Meier survival were carried out.
people exposed to MDD during the follow-up were 107/263 (40.7%). Among them, 36 deceased during the observation period. Overtime, having MDD and death' occurrence showed a strong association (RR=2.15; 95% CI (1.10-4.20); χ²=5.224, p=0.0022), confirmed by Kaplan-Meier survival analysis (χ²=4.357, p=0.037). Among people who died, there was not any association between MDD, age, gender, HRQoL, cancer stage and site.
the study confirms the association between MDD and early death in people with cancer. The absence of any association between the onset of MDD and advanced stage of cancer may suggest that it could be due to the consequences of MDD in worsening the clinical conditions related to cancer. The findings point out the relevance of MDD' early detention among people with cancer.
目的是验证重度抑郁症（MDD）与肿瘤疾病患者过早死亡风险之间的关联，并从纵向角度收集有关可能关联因果关系的证据。
这是一项为期9个月的队列研究，涉及实体癌或血液系统癌症患者。通过专门设计的表格收集社会人口统计学和临床肿瘤学数据，使用PHQ-9筛查MDD（临界值≥10），使用SF-12评估健康相关生活质量（HRQoL）。对暴露于MDD和未暴露于MDD的患者进行早期死亡相对风险（RR）分析以及Kaplan-Meier生存分析。
随访期间暴露于MDD的患者为107/263（40.7%）。其中，36人在观察期内死亡。随着时间推移，患有MDD与死亡发生之间显示出强烈关联（RR=2.15；95%置信区间（1.10 - 4.20）；χ²=5.224，p=0.0022），Kaplan-Meier生存分析证实了这一点（χ²=4.357，p=0.037）。在死亡患者中，MDD、年龄、性别、HRQoL、癌症分期和部位之间没有任何关联。
该研究证实了MDD与癌症患者早期死亡之间的关联。MDD的发生与癌症晚期之间不存在任何关联，这可能表明这是由于MDD导致与癌症相关临床状况恶化的结果。研究结果指出了在癌症患者中早期发现MDD的重要性。
