La Nasa Giorgio, Caocci Giovanni, Morelli Emanuela, Massa Elena, Farci Antonio, Deiana Laura, Pintus Elisa, Scartozzi Mario, Sancassiani Federica
Ematologia e CTMO, Ospedale Businco, Azienda Ospedaliera Brotzu, Cagliari, Italy.
Dipartimento di Scienze Mediche e Sanita Pubblica, Universita di Cagliari, Cagliari, Italy.
Clin Pract Epidemiol Ment Health. 2020 Jul 30;16:174-179. doi: 10.2174/1745017902016010174. eCollection 2020.
HRQoL is generally conceptualized as a broad multidimensional construct that refers to patients' perceptions of the impact of disease and its treatment on their physical, psychological, and social functioning and well-being. Little is known in patients with onco-hematological cancer in comparison with the general population and other chronic diseases.
We assessed HRQoL in patients diagnosed with haematological cancers in comparison with the general population and other chronic diseases.
The questionnaire Short Form (SF)-12 was administered to 62 patients with onco-hematological disease and results were compared with 702 controls (184 healthy people, 37 Major Depression, 201 Multiple Sclerosis; 23 Wilson disease; 46 Carotidal Atherosclerosis; 60 Celiac disease; 151 solid tumours).
HRQoL in patients diagnosed with a haematological cancer was significantly worse in comparison with the general population (F= 43.853, p <0.00001) but similar when compared with solid tumour and other chronic diseases such as Major Depression and Carotid Atherosclerosis. In addition, HRQoL in patients diagnosed with a haematological cancer was significantly higher than that due to Celiac disease (p <0.00001) and Wilson's disease (p= 0.02), and lower than that due to Multiple Sclerosis (p= 0.032).
This study confirmed that haematological cancers negatively affects overall HRQoL. The results showed an impact of haematological cancers on HRQoL that is similar to what found in patients with solid tumors, Major Depression and Carotid Atherosclerosis. Current successful therapeutic strategy achieved in the treatment of haematological cancers not only positively impact on survival rate but also could improve the overall HRQoL.
健康相关生活质量（HRQoL）通常被概念化为一个广泛的多维度结构，指患者对疾病及其治疗对其身体、心理和社会功能及幸福感影响的认知。与普通人群和其他慢性病患者相比，血液肿瘤患者的这方面情况鲜为人知。
我们评估了被诊断为血液系统癌症的患者的健康相关生活质量，并与普通人群和其他慢性病患者进行比较。
对62例血液肿瘤疾病患者进行了简短健康调查问卷（SF-12），并将结果与702名对照者（184名健康人、37名重度抑郁症患者、201名多发性硬化症患者、23名威尔逊病患者、46名颈动脉粥样硬化患者、60名乳糜泻患者、151名实体肿瘤患者）进行比较。
与普通人群相比，被诊断为血液系统癌症的患者的健康相关生活质量显著更差（F = 43.853，p < 0.00001）；但与实体肿瘤患者以及其他慢性病患者（如重度抑郁症患者和颈动脉粥样硬化患者）相比则相似。此外，被诊断为血液系统癌症的患者的健康相关生活质量显著高于乳糜泻患者（p < 0.00001）和威尔逊病患者（p = 0.02），低于多发性硬化症患者（p = 0.032）。
本研究证实血液系统癌症对整体健康相关生活质量有负面影响。结果显示血液系统癌症对健康相关生活质量的影响与实体肿瘤患者、重度抑郁症患者和颈动脉粥样硬化患者相似。目前在血液系统癌症治疗中取得的成功治疗策略不仅对生存率有积极影响，还可改善整体健康相关生活质量。
