Department of Cardiology, 52979Koc University Hospital, Istanbul, Turkey.
Angiology. 2022 Feb;73(2):177-181. doi: 10.1177/00033197211014678. Epub 2021 May 7.
We evaluated if admission glycosylated hemoglobin (HbA) and fasting glucose levels are correlated with the severity of coronary artery disease (CAD) in non-ST-elevation myocardial infarction (NSTEMI), nondiabetic, patients. Coronary artery disease severity, according to the anatomical synergy between percutaneous coronary intervention (PCI) with taxus and cardiac surgery (SYNTAX) score 2 (SSII), was retrospectively evaluated in 359 nondiabetic patients hospitalized with NSTEMI who underwent coronary angiography. Glucose intolerance was assessed by serum fasting glucose and HbA levels. We stratified patients according to tertiles of SSII (≤21.5, 21.5-30.6, and ≥30.6). These score ranges were defined as SSII low, SSII mid, and SSII high, respectively. The average age of the patients was 57.1 ± 10.9 years; 189 (52.1%) patients were males. The average fasting glucose was 114 ± 52 mg/dL, HbA was 5.8% ± 0.9%, and SSII was 18.9 ± 10.3. A stronger correlation was found between HbA and SSII than fasting glucose and SSII (r1 = 0.901, < .001, r2 = 0.378, < .001, respectively), and HbA level and hypertension were independent risk factors for SSII high (odds ratio [OR]: 2.2 (95% CI: 0.5-9.0, < .001; OR: 1.1 (1.0-1.3), = .007, respectively). In conclusion, in nondiabetic patients with NSTEMI, HbA levels correlated with CAD severity as measured by the SSII.
我们评估了非 ST 段抬高型心肌梗死（NSTEMI）、非糖尿病患者入院时糖化血红蛋白（HbA）和空腹血糖水平与冠状动脉疾病（CAD）严重程度的相关性。在接受冠状动脉造影的 359 例非糖尿病 NSTEMI 住院患者中，回顾性评估了根据经皮冠状动脉介入治疗（PCI）与紫杉醇的解剖协同作用和心脏手术（SYNTAX）评分 2（SSII）评估的 CAD 严重程度。葡萄糖耐量通过血清空腹血糖和 HbA 水平评估。我们根据 SSII 的三分位（≤21.5、21.5-30.6 和≥30.6）将患者分层。这些评分范围分别定义为 SSII 低、SSII 中、SSII 高。患者的平均年龄为 57.1 ± 10.9 岁；189 例（52.1%）为男性。平均空腹血糖为 114 ± 52 mg/dL，HbA 为 5.8% ± 0.9%，SSII 为 18.9 ± 10.3。与空腹血糖和 SSII 相比，HbA 与 SSII 之间的相关性更强（r1 = 0.901，<.001，r2 = 0.378，<.001），HbA 水平和高血压是非 SSII 高的独立危险因素（比值比[OR]：2.2（95%CI：0.5-9.0，<.001；OR：1.1（1.0-1.3），=.007）。总之，在非糖尿病 NSTEMI 患者中，HbA 水平与 SSII 测量的 CAD 严重程度相关。
