Saraei Koushki Majid, Parizad Razieh, Abdollahzadeh Ali, Separham Ahmad
Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Caspian J Intern Med. 2025 Jun 23;16(3):519-524. doi: 10.22088/cjim.16.3.519. eCollection 2025 Summer.
Glycated hemoglobin A1c (HbA1c) level is related to increased cardiovascular diseases (CVDs) and death, even in non-diabetic subjects. Although in ST-elevation myocardial infarction (STEMI) cases, the association between HbA1c and coronary artery disease (CAD) remains unclear.
This cross-sectional study was conducted on 167 non-diabetic STEMI patients undergoing primary percutaneous coronary intervention (PCI). The SYNTAX score was utilized to evaluate CAD severity. Cases were categorized into three groups based on the HbA1c levels: <5%, 5.1-5.9%, and 6-6.5%.
SYNTAX scores significantly increased in the cases with 6 to 6.5 HbA1c levels compared to the other group (28.9±9.5 vs 21.2±5.2 vs 13.7±4.5, P=0.000). Additionally, death was more elevated in this group (4% vs 0% vs 0%, P=0.006).
Higher HbA1c levels are strongly associated with coronary atherosclerosis in non-diabetic patients that present with non-diabetic STEMI. Consequently, in non-diabetic STEMI patients, HbA1c may be able to predict the severity of CAD.
糖化血红蛋白A1c（HbA1c）水平与心血管疾病（CVD）及死亡风险增加相关，即便在非糖尿病患者中亦是如此。尽管在ST段抬高型心肌梗死（STEMI）病例中，HbA1c与冠状动脉疾病（CAD）之间的关联仍不明确。
本横断面研究纳入了167例接受直接经皮冠状动脉介入治疗（PCI）的非糖尿病STEMI患者。采用SYNTAX评分评估CAD严重程度。根据HbA1c水平将病例分为三组：<5%、5.1 - 5.9%和6 - 6.5%。
与其他组相比，HbA1c水平在6至6.5%的病例中SYNTAX评分显著升高（28.9±9.5 vs 21.2±5.2 vs 13.7±4.5，P = 0.000）。此外，该组的死亡率更高（4% vs 0% vs 0%，P = 0.006）。
较高的HbA1c水平与非糖尿病STEMI患者的冠状动脉粥样硬化密切相关。因此，在非糖尿病STEMI患者中，HbA1c可能能够预测CAD的严重程度。
