Merder Erkan, Arıman Ahmet, Dinçer Selvi, Altunrende Fatih
Urology, Prof.Dr.Cemil Taşçıoğlu City Hospital, University of Health Sciences, Istanbul, Turkey.
Prof.Dr.Cemil Taşçıoğlu City Hospital Radiation Oncology, University of Health Sciences, Istanbul.
Urologia. 2022 May;89(2):203-209. doi: 10.1177/03915603211014864. Epub 2021 May 7.
We investigated role of neutrophil-to-lymphocyte ratio (NLR) in the diagnosis and prediction of extracapsular extension (ECE) in clinically localized prostate cancer (PCa).
A total of 396 patients with clinically localized PCa who underwent open radical retropubic prostatectomy (RRP), and 260 patients with benign prostatic hyperplasia (BPH) who underwent suprapubic prostatectomy were included in the study. Preoperative NLR, prostate specific antigen (PSA), prostate specific antigen density (PSAD), free PSA, prostate volume (PV), free/total PSA (f/t PSA) in both groups, and relation of NLR with PSA, Gleason Score (GS), and pathologic stage in PCa group were investigated. Records of patients were analyzed retrospectively.
NLR, free PSA, f/t PSA, and PV were statistically higher in BHP, and PSAD was higher in PCa group. In PCa group, NLR was found to be higher in patients with PSA >10 ng/ml compared to those with less than ⩽10 ng/ml. NLR increases as the preoperative GS increases, and it was higher in pT3 patients than pT2 patients. NLR was statistically higher in those patients with positive lymph nodes than those without after RRP ( = 0.029).
NLR is not a sufficient biomarker in differentiating clinically localized PCa from BPH. NLR increases as preoperative GS and pathologic stage increases. Lymph node involved patients after RRP have statistically higher NLR. NLR can be an indicator of ECE and lymph-node involvement in clinically localized PCa.
我们研究了中性粒细胞与淋巴细胞比值（NLR）在临床局限性前列腺癌（PCa）的包膜外侵犯（ECE）诊断及预测中的作用。
本研究纳入了396例行开放性耻骨后根治性前列腺切除术（RRP）的临床局限性PCa患者，以及260例行耻骨上前列腺切除术的良性前列腺增生（BPH）患者。研究了两组患者术前的NLR、前列腺特异性抗原（PSA）、前列腺特异性抗原密度（PSAD）、游离PSA、前列腺体积（PV）、游离/总PSA（f/t PSA），以及PCa组中NLR与PSA、 Gleason评分（GS）和病理分期的关系。对患者的记录进行回顾性分析。
BPH患者的NLR、游离PSA、f/t PSA和PV在统计学上更高，而PCa组的PSAD更高。在PCa组中，PSA>10 ng/ml的患者NLR高于PSA≤10 ng/ml的患者。NLR随着术前GS的增加而升高，pT3患者的NLR高于pT2患者。RRP术后有阳性淋巴结的患者NLR在统计学上高于无阳性淋巴结的患者（P = 0.029）。
NLR在区分临床局限性PCa和BPH方面不是一个充分的生物标志物。NLR随着术前GS和病理分期的增加而升高。RRP术后有淋巴结受累的患者NLR在统计学上更高。NLR可以作为临床局限性PCa中ECE和淋巴结受累的一个指标。
