Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, 14476 Potsdam, Germany.
Freie Universität Berlin, Institute of Chemistry and Biochemistry, 14195 Berlin, Germany.
J Org Chem. 2021 May 21;86(10):7280-7287. doi: 10.1021/acs.joc.1c00505. Epub 2021 May 7.
Galactofurans are an important structural constituent of arabinogalactan and lipopolysaccharides (LPS) ubiquitously present on the envelopes of all . Key to the automated glycan assembly (AGA) of linear galactofuranosides as long as 20-mers was the identification of thioglycoside building blocks with a fine balance of stereoelectronic and steric effects to ensure the stability of oligogalactofuranoside during the synthesis. A benzoylated galactofuranose thioglycoside building block proved most efficient for oligosaccharide construction.
半乳呋喃聚糖是阿拉伯半乳聚糖和脂多糖（LPS）的重要结构组成部分，普遍存在于所有的包膜上。关键的自动糖基化组装（AGA）的线性半乳呋喃糖长达 20 个单体，是鉴定具有精细平衡的立体电子和空间效应的硫糖苷砌块，以确保寡半乳呋喃糖在合成过程中的稳定性。苯甲酰化半乳呋喃糖硫糖苷砌块被证明对寡糖构建最有效。
