镍催化的 1,6-二烯的去对称环化反应构建季立体中心。
Nickel-Catalyzed Desymmetrizing Cyclization of 1,6-Dienes to Construct Quaternary Stereocenters.
机构信息
State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China.
出版信息
Org Lett. 2021 May 21;23(10):3814-3817. doi: 10.1021/acs.orglett.1c00796. Epub 2021 May 7.
PMID:33960795
Abstract
A highly enantioselective and diastereoselective nickel-catalyzed desymmetrizing cyclization of 1,6-dienes was developed by using chiral spiro phosphoramidite ligands. The reaction provides a new atom- and step-economical approach to chiral spiro lactones and analogues bearing a quaternary stereocenter.
摘要
发展了一种高对映选择性和非对映选择性的镍催化 1,6-二烯去对称环化反应，使用手性螺环磷酰胺配体。该反应为手性螺内酯和带有季立体中心的类似物提供了一种新的原子经济性和步骤经济性方法。
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