Digestive Surgery Unit, Fondazione Policlinico Agostino Gemelli IRCCS di Roma, Rome, Italy.
Università Cattolica del Sacro Cuore di Roma, Rome, Italy.
Scand J Gastroenterol. 2021 Jul;56(7):784-790. doi: 10.1080/00365521.2021.1921256. Epub 2021 May 7.
The incidence of adhesive bowel obstruction (ASBO) progressively increases with age. Strong evidences on the influencing role of age on ASBO clinical course and management are still lacking. Aim of this study is to retrospectively analyze the clinical outcomes of patients older than 65 years of age admitted to a tertiary referral Emergency Department with a diagnosis of ASBO.
We reviewed the clinical records of patients admitted for ASBO in the period 2014-2019. Patients were divided in elderly (≥65 years) and non-elderly (<65 years). Primary endpoint was to compare the all-cause in-hospital mortality and the occurrence of major complications in the two groups. Secondary endpoint was a comparison of clinical presentation, clinical course and management.
We enrolled 285 elderly and 492 non-elderly patients. Vomit was more frequent in the elderly (51.9% vs 34.6%; < .001), while no difference was evidenced for the remaining symptoms of ASBO presentation. A higher rate of non-operative management (NOM) (26.3% vs 16.5%; = .010), ICU admission (16% vs 0.6%; < .001), mortality (2.1% vs 0.2%; = .007) and cumulative major complications (8.8% vs 3.3%; = .001), as well as a prolonged hospitalization (8.2 vs 5.4 days; < .001) was evidenced in the ≥65 years group. Multivariate analysis identified increasing age (OR:2.8; 95%CI:1.09-7.2; = .040) and Charlson comorbidity index ≥ 2 (OR:2.5; 95% CI:1.2-6.4; = .050) as the only independent predictors of cumulative major complications.
Despite the similarity in terms of clinical presentation, elderly patient present higher mortality rate and occurrence of major complications. A comprehensive geriatric assessment is recommended to optimize the diagnostic and clinical strategies in case of ASBO.
粘连性肠梗阻(ASBO)的发病率随年龄增长而逐渐增加。尽管有大量证据表明年龄对 ASBO 临床病程和治疗有影响,但目前仍缺乏相关的有力证据。本研究旨在回顾性分析就诊于三级转诊急诊部的诊断为 ASBO 的老年(≥65 岁)和非老年(<65 岁)患者的临床结局。
我们回顾了 2014 年至 2019 年期间因 ASBO 入院的患者的临床记录。将患者分为老年(≥65 岁)和非老年(<65 岁)组。主要终点是比较两组患者的全因院内死亡率和主要并发症的发生情况。次要终点是比较两组患者的临床表现、临床病程和治疗方法。
共纳入 285 例老年患者和 492 例非老年患者。老年患者呕吐更为常见(51.9%比 34.6%;<0.001),而 ASBO 表现的其他症状则无差异。非手术治疗(NOM)(26.3%比 16.5%;=0.010)、入住 ICU(16%比 0.6%;<0.001)、死亡率(2.1%比 0.2%;=0.007)和累积主要并发症(8.8%比 3.3%;=0.001)的发生率更高,且住院时间更长(8.2 比 5.4 天;<0.001)。多因素分析显示,年龄增长(OR:2.8;95%CI:1.09-7.2;=0.040)和Charlson 合并症指数≥2(OR:2.5;95%CI:1.2-6.4;=0.050)是累积主要并发症的唯一独立预测因素。
尽管临床表现相似,但老年患者的死亡率和主要并发症发生率更高。建议对老年患者进行全面的老年评估,以优化 ASBO 的诊断和临床策略。