Department of Infectious Diseases, Ramon y Cajal Hospital, Madrid, Spain.
Laboratory of Immunovirology, Ramón y Cajal Hospital, Madrid, Spain.
J Infect Dis. 2021 Jul 15;224(2):241-245. doi: 10.1093/infdis/jiab242.
We investigated the duration of humoral and T-cell immune response in paired samples among 22 convalescent healthcare workers (HCWs). A median of 1.8 months after diagnosis, T-cell response was significantly lower in HCWs with early loss of antibodies (6 cases [27%]). After 5.1 months, antibody decline was observed in 77% of cases (41% seroreverted; P < .01), and 36% had lost T-cell response (75% lost response to spike protein). Persistence of immune response was observed in those who developed a greater adaptive immune response. Our data point to the initial immune response as the relevant player in coronavirus disease 2019 duration of protection.
我们调查了 22 名恢复期医护人员（HCWs）配对样本中的体液和 T 细胞免疫反应持续时间。在诊断后中位数为 1.8 个月时，抗体早期丢失的 HCWs 中的 T 细胞反应明显降低（6 例[27%]）。5.1 个月后，77%的病例出现抗体下降（41%血清学转换；P<.01），36%的病例失去 T 细胞反应（75%对刺突蛋白失去反应）。在那些产生更大适应性免疫反应的人中观察到免疫反应的持久性。我们的数据表明，初始免疫反应是导致 2019 年冠状病毒病保护持续时间的相关因素。
