当细胞内的LUC7L2水平下降时，可变剪接会重新调整代谢以进行氧化磷酸化。
When cells are down on their LUC7L2, alternative splicing rewires metabolism for OXPHOS.
作者信息
Hoskins Aaron A, Rhoads Timothy W
机构信息
Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA; Department of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.
Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
出版信息
Mol Cell. 2021 May 6;81(9):1859-1860. doi: 10.1016/j.molcel.2021.04.003.
PMID:33961773
Abstract
Daniels et al. (2021) and Jourdain et al. (2021) identify LUC7L2 as a component of the U1 snRNP capable of reprogramming cellular metabolism through changes in alternative pre-mRNA splicing.
摘要
丹尼尔斯等人（2021年）和朱尔丹等人（2021年）将LUC7L2鉴定为U1小核核糖核蛋白的一个组成部分，该蛋白能够通过改变前体mRNA可变剪接来重新编程细胞代谢。
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